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Abstract: Objective: To investigate the relationship between serum resistin level and acute coronary syndrome (ACS) or stable angina pectoris (SAP). Methods: Sixty-five patients, with coronary artery disease, were enrolled and divided into three subgroups: acute myocardial infarction (AMI), unstable angina pectoris (UAP) and SAP, and 26 healthy people were recruited as controls in the cross-sectional study. Serum resistin levels were determined by ELISA (enzyme-linked immunosorbent assay), and WBC (white blood cell count), hsCRP (high sensitive C-reaction protein), CK_max (maximum of creatinkinase), CK-MB_max (maximum of isozyme of creatinkinase) and cTnI_max (maximum of troponin) were measured by standard laboratory methods. Results: The serum resistin levels were 4 folds higher in AMI patients, 2.43 folds in UAP patients and 1.12 folds in SAP patients than in the healthy controls (P<0.05). The resistin levels were also significantly different between AMI [(8.16±0.79) ng/ml], UAP [(5.59±0.75) ng/ml] and SAP [(3.45±0.56) ng/ml] groups (P<0.01); WBC, hsCRP, CK_max, CK-MB_max and cTnI_max were significantly increased in AMI patients over UAP and SAP patients. Spearman analysis showed that serum resistin levels were positively correlated with WBC (r=0.412, P=0.046), hsCRP (r=0.427, P=0.037), CK_max, CK-MB_max and cTnI_max (r=0.731, 0.678, 0.656; P<0.01). Conclusion: Serum resistin levels increased with inflammatory factors and myocardial impairment. The results suggest that human resistin might play an important role in the pathogenesis of atherosclerosis and AMI as an inflammatory factor.

[1] Agwunobi, A., Reid, C., Maycock, P., Little, R.A., Carlson, G.L., 2000. Insulin resistance and substrate utilization in human endotoxemia. J. Clin. Endocrinol. Metab., 85(10):3770-3778.

[2] Burnett, M.S., Lee, C.W., Kinnaird, T.D., Stabile, E., Durrani, S., Dullum, M.K., Devaney, J.M., Fishman, C., Stamou, S., Canos, D., et al., 2005. The potential role of resistin in atherogenesis. Atherosclerosis, 182(2):241-248.

[3] Calabro, P., Samudio, I., Willerson, J.T., 2004. Resistin promotes smooth muscle cell proliferation through activation of extra cellular signal regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation, 110(21):3335-3340.

[4] Fan, H.Q., Gu, N., Liu, F., Pan, X.Q., Guo, M., Chen, R.H., Guo, X.R., 2007. Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles. Acta Pharmacol. Sin., 28(3):410-416.

[5] Hotamisligil, G.S., Spiegelman, B.M., 1994. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes, 43(11):1271-1278.

[6] Kaser, S., Kaser, A., Sandhofer, A., 2003. Resistin messenger-RNA expression is increased by proinflammatory cytcokines in vitro. Biochem. Biophys. Res. Commun., 309(2):286-290.

[7] Kawanami, D., Maemura, K., Takeda, N., Harada, T., Nojiri, T., Imai, Y., Manabe, I., Utsunomiya, K., Nagai, R., 2004. Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem. Biophys. Res. Commun., 314(2):415-419.

[8] Kunnari, A., Ukkola, O., Paivansalo, M., Kesaniemi, Y.A., 2006. High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes. J. Clin. Endocrinal. Metab., 91(7):2755-2760.

[9] Lehrke, M., Reilly, M.P., Millington, S.C., Iqbal, N., Rader, D.J., Lazar, M.A., 2004. An inflammatory cascade leading to hyperresistinemia in humans. Plos. Med., 1(2):e45.

[10] Lubos, E., Messow, C., Schnabel, R., Rupprecht, H., Espinola-Klein, C., Bickel, C., Peetz, D., Post, F., Lackner, K., Tiret, L., 2007. Resistin, acute coronary syndrome and prognosis results from the AtheroGene study. Athero-sclerosis, 193(1):121-128.

[11] Lyon, C.J., Law, R.E., Hsueh, W.A., 2003. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology, 144(6):2195-2200.

[12] Mather, K.J., Verma, S., Anderson, T.J., 2001. Improved endothelial function with metformin in type 2 diabetes mellitus. J. Am. Coll. Cardiol., 37(5):1344-1350.

[13] Matsuzawa, Y., Funahashi, T., Nakamura, T., 1999. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocytederived bioactive substances. Ann. N. Y. Acad. Sci., 892:146-154.

[14] Ohmori, R., Momiyama, Y., Kato, R., Taniguchi, H., Ogura, M., Ayaori, M., Nakamura, H., Ohsuzu, F., 2005. Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease. J. Am. Coll. Cardiol., 46(2):379-380.

[15] Patel, L., Buckels, A.C., Kinghorn, I.J., Murdock, P.R., Holbrook, J.D., Plumpton, C., Macphee, C.H., Smith, S.A., 2003. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem. Biophys. Res. Commun., 300(2):472-476.

[16] Pischon, T., Bamberger, C.M., Kratzsch, J., Zyriax, B.C., Algenstaedt, P., Boeing, H., Windler, E., 2005. Association of plasma resistin levels with coronary heart disease in women. Obes. Res., 13(10):1764-1771.

[17] Rajala, M.W., Obici, S., Scherer, P.E., Rossetti, L., 2003. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J. Clin. Invest., 111(2):225-230.

[18] Reilly, M.P., Lehrke, M., Wolfe, M.L., Rohatgi, A., Lazar, M.A., Rader, D.J., 2005. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation, 111(7):932-939.

[19] Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S., Lazar, M.A., 2001a. The hormone resistin links obesity to diabetes. Nature, 409(6818):307-312.

[20] Steppan, C.M., Brown, E.J., Wright, C.M., Bhat, S., Banerjee, R.R., Dai, C.Y., Enders, G.H, Silberg, D.G., Wen, X., Wu, G.D., Lazar, M.A., 2001b. A family of tissue-specific resistin-like molecules. Proc. Natl. Acad. Sci. USA, 98(2):502-506.

[21] Steppan, C.M., Wang, J., Whiteman, E.L., Birnbaum, M.J., Lazar, M.A., 2005. Activation of SOCS-3 by resistin. Mol. Cell. Biol., 25(4):1569-1575.

[22] Verma, S., Anderson, T.J., 2002. Fundamentals of endothelial function for the clinical cardiologist. Circulation, 105(5):546-549.

[23] Verma, S., Li, S.H., Wang, C.H., Fedak, P.W., Li, R.K., Weisel, R.D., Mickle, D.A., 2003. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation, 108(6):736-740.

[24] Yang, R.Z., Huang, Q., Xu, A., McLenithan, J.C., Eisen, J.A., Shuldiner, A.R., Alkan, S., Gong, D.W., 2003. Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem. Biophys. Res. Commun., 310(3):927-935.

[25] Zhou, L., Li, Y., Xia, T., Feng, S., Chen, X., Yang, Z., 2006. Resistin overexpression impaired glucose tolerance in hepatocytes. Eur. Cytokine. Netw., 17(3):189-195.