An enhanced boronic acid-functionalized bimetallic metal-organic-framework fluorescent probe for rapid and selective fluorescence detection of epinephrine in human serum and urine
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Yixuan NI1, Changyu CHEN1, Baoqi LUO1, Jianliang LI1, Ming GUO2, Qiao DENG1, Jingjing XU1, Dan WEI1, Xu WANG1. An enhanced boronic acid-functionalized bimetallic metal-organic-framework fluorescent probe for rapid and selective fluorescence detection of epinephrine in human serum and urine[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="An enhanced boronic acid-functionalized bimetallic metal-organic-framework fluorescent probe for rapid and selective fluorescence detection of epinephrine in human serum and urine",
author="Yixuan NI1, Changyu CHEN1, Baoqi LUO1, Jianliang LI1, Ming GUO2, Qiao DENG1, Jingjing XU1, Dan WEI1, Xu WANG1",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2500791"
}
%0 Journal Article
%T An enhanced boronic acid-functionalized bimetallic metal-organic-framework fluorescent probe for rapid and selective fluorescence detection of epinephrine in human serum and urine
%A Yixuan NI1
%A Changyu CHEN1
%A Baoqi LUO1
%A Jianliang LI1
%A Ming GUO2
%A Qiao DENG1
%A Jingjing XU1
%A Dan WEI1
%A Xu WANG1
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1869-1951
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2500791
TY - JOUR
T1 - An enhanced boronic acid-functionalized bimetallic metal-organic-framework fluorescent probe for rapid and selective fluorescence detection of epinephrine in human serum and urine
A1 - Yixuan NI1
A1 - Changyu CHEN1
A1 - Baoqi LUO1
A1 - Jianliang LI1
A1 - Ming GUO2
A1 - Qiao DENG1
A1 - Jingjing XU1
A1 - Dan WEI1
A1 - Xu WANG1
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP - 0
%@ 1869-1951
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2500791
Abstract: epinephrine (EP) is a pivotal hormone and neurotransmitter, and its accurate quantification is crucial for evaluating stress responses, diagnosing pathological conditions, and maintaining physiological homeostasis. However, conventional analytical methods are often constrained by limited sensitivity, long detection times, and high costs, necessitating innovative strategies that reconcile analytical rigor with practical applicability. In this work, we present a boronic acid-functionalized bimetallic Zn-Eu metal-organic framework (Zn-Eu-MOF) as a highly sensitive fluorescent probe for EP detection. Owing to the synergistic Zn-Eu bimetallic architecture and an efficient light-harvesting ligand, the probe exhibits intense fluorescence and a rapid response toward EP. The integration of boronic acid groups facilitates selective recognition of the cis-diol structure of EP's, ensuring reliable performance in complex biological matrices. The sensor developed here offers a wide linear detection range (0.4-500 µmol/L), high sensitivity (LOD=0.12 µmol/L), and excellent selectivity. It successfully quantified EP in human serum and urine samples, achieving average recovery rates of 94.8%-115.1%. This study provides a high-performance platform for the rapid and sensitive fluorescence-based determination of EP, offering significant potential for biomedical diagnostics and point-of-care testing.
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