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CLC number: TG146.13; TG665; R318.08

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2020-10-16

Cited: 0

Clicked: 4040

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

You-wen Yang

https://orcid.org/0000-0003-1557-0252

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Journal of Zhejiang University SCIENCE A 2020 Vol.21 No.11 P.876-891

http://doi.org/10.1631/jzus.A2000186


Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn–Nd alloy


Author(s):  Ci-jun Shuai, Ming-li Yang, Fang Deng, You-wen Yang, Shu-ping Peng, Fang-wei Qi, Chong-xian He, Li-da Shen, Hui-xin Liang

Affiliation(s):  Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China; more

Corresponding email(s):   yangyouwen@csu.edu.cn, shuping@csu.edu.cn

Key Words:  Zn–, Nd alloy, Laser powder bed fusion (LPBF), Anti-inflammatory activity, Mechanical properties


Ci-jun Shuai, Ming-li Yang, Fang Deng, You-wen Yang, Shu-ping Peng, Fang-wei Qi, Chong-xian He, Li-da Shen, Hui-xin Liang. Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn–Nd alloy[J]. Journal of Zhejiang University Science A, 2020, 21(11): 876-891.

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author="Ci-jun Shuai, Ming-li Yang, Fang Deng, You-wen Yang, Shu-ping Peng, Fang-wei Qi, Chong-xian He, Li-da Shen, Hui-xin Liang",
journal="Journal of Zhejiang University Science A",
volume="21",
number="11",
pages="876-891",
year="2020",
publisher="Zhejiang University Press & Springer",
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%T Forming quality, mechanical properties, and anti-inflammatory activity of additive manufactured Zn–Nd alloy
%A Ci-jun Shuai
%A Ming-li Yang
%A Fang Deng
%A You-wen Yang
%A Shu-ping Peng
%A Fang-wei Qi
%A Chong-xian He
%A Li-da Shen
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A1 - Shu-ping Peng
A1 - Fang-wei Qi
A1 - Chong-xian He
A1 - Li-da Shen
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DOI - 10.1631/jzus.A2000186


Abstract: 
Zinc (Zn) has recently been recognized as a promising bone repair material due to its inherent biodegradability and favorable biocompatibility. In this work, rare earth neodymium (Nd) was introduced into a Zn-based alloy fabricated using a laser powder bed fusion (LPBF) process. Results showed that addition of Nd significantly improved the melt fluidity and reduced the evaporation of Zn, thereby achieving parts with a high densification rate of 98.71%. Significantly, the nd alloying treatment effectively refined the grain size from 25.3 to 6.2 μm. NdZn5 eutectics precipitated and contributed to a second-phase strengthening effect. As a result, the tensile strength increased to (119.3±5.1) MPa and the Vickers hardness to (76.2±4.1). Moreover, the zn–;nd alloy exhibited good anti-inflammatory activity, as the Nd ions released during degradation had a strong affinity with cell membrane phospholipids and consequently inhibited the release of inflammatory cytokines. It also presented favorable cytocompatibility, showing great potential as a bone repair material.

增材制造制备Zn-Nd合金的成形质量、力学性能及抗炎活性

目的:锌具有良好的降解性能和生物相容性,被视为一种很有前途的骨修复材料.然而,锌金属作为骨植入物时的力学强度难以满足承重骨修复的需求,并存在炎症反应的风险.本文旨在探讨稀土钕合金化对锌骨植入物激光成形质量的影响,为改善锌合金的成形质量、提高力学性能及增加抗炎活性提供理论依据.
创新点:1. 在增材制造过程中,添加钕能够有效改善锌基合金的成形质量;2. 稀土钕提高了锌基合金的力学性能,同时也赋予了抗炎活性.
方法:1. 通过实验对比锌钕合金的表面形貌,计算出相应的致密度,并分析钕对锌基合金成形质量的影响(图2);2. 基于不同实验对比锌钕合金的微观组织结构及力学强度的变化,并探讨稀土钕提高力学性能的原因(图3~5和表1);3. 通过电化学实验和浸泡实验,分析稀土钕对降解性能的影响(图6和7);4. 基于体外生物学实验,对比分析钕对抗炎活性和细胞活性的影响(图8和9).
结论:1. 稀土钕提高了激光增材制造锌合金的成形质量,并使其致密化率高达98.71%;2. 钕合金化有助于晶粒细化和第二相强化,使极限抗拉强度提高到了(119.3±5.1) MPa;3. 钕合金化能抑制促炎因子的释放,促进抗炎因子的释放,进而使锌钕部分具有良好的抗炎活性,而细胞培养试验也表明其具有良好的生物相容性.

关键词:锌钕合金;激光粉末熔融;抗炎活性;力学性能

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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