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Abstract: Objective: To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis. Methods: NAT activity in apoptotic hepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of hepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry. Results: NAT activity was lowered in apoptotic hepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in hepG2 cells. Conclusion: NAT can inhibit apoptosis in hepG2 cells.

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