JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.1 P.1-9

Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

Author(s): Ching-hung LIN, Huang-chun LIEN, Fu-chang HU, Yen-shen LU, Sung-hsin KUO, Ling-chu WU, San-lin YOU, Ann-lii CHENG, King-jen CHANG, Chiun-sheng HUANG
Affiliation(s): Department of Oncology, National Taiwan University Hospital, Taiwan, Taipei 10016; more
Corresponding email(s): huangcs@ntu.edu.tw
Key Words: Breast cancer, Fractionated evaluation, Estrogen receptor, Progesterone receptor

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Abstract: Objective: To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods: Patients with stages I�III breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor (ER) and progesterone receptor (PR) was evaluated by immunohistochemistry (IHC). A fractionated score (F score), the percentage of positive-staining nuclei (0=none, 1=1%�10%, 2=11%�30%, 3=31%�50%, 4=51%�70%, and 5=71%�100%), was assigned to each case. The dichotomized scoring method defines an F score >1 as positive. The prognostic values of both scores were compared by multiple Cox�s proportional hazard models of disease-free survival (DFS) and overall survival (OS). Results: Four hundred and sixteen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox�s proportional hazard models. Conclusion: Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment.

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