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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2022-08-12
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Sergey VTORUSHIN, Anastasia DULESOVA, Nadezhda KRAKHMAL. Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features[J]. Journal of Zhejiang University Science B, 2022, 23(8): 617-624.
@article{title="Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features",
author="Sergey VTORUSHIN, Anastasia DULESOVA, Nadezhda KRAKHMAL",
journal="Journal of Zhejiang University Science B",
volume="23",
number="8",
pages="617-624",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200113"
}
%0 Journal Article
%T Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features
%A Sergey VTORUSHIN
%A Anastasia DULESOVA
%A Nadezhda KRAKHMAL
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 8
%P 617-624
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200113
TY - JOUR
T1 - Luminal androgen receptor (LAR) subtype of triple-negative breast cancer: molecular, morphological, and clinical features
A1 - Sergey VTORUSHIN
A1 - Anastasia DULESOVA
A1 - Nadezhda KRAKHMAL
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 8
SP - 617
EP - 624
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200113
Abstract: According to the classification presented by Lehmann BD (2016), triple-negative breast cancer (TNBC) is a heterogeneous group of malignant tumors with four specific subtypes: basal-like (subtype 1 and subtype 2), mesenchymal, and luminal androgen receptor (LAR) subtypes. The basal-like subtypes of carcinomas predominate in this group, accounting for up to 80% of all cases. Despite the significantly lower proportions of mesenchymal and LAR variants in the group of breast carcinomas with a TNBC profile, such tumors are characterized by aggressive biological behavior. To this end, the LAR subtype is of particular interest, since the literature on such tumors presents different and even contradictory data concerning the disease course and prognosis. This review is devoted to the analysis of the relevant literature, reflecting the main results of studies on the molecular properties and clinical features of the disease course of LAR-type TNBC carcinomas.
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