CLC number: R459.9
On-line Access: 2011-11-30
Received: 2010-11-22
Revision Accepted: 2011-10-26
Crosschecked: 2011-11-10
Cited: 7
Clicked: 5839
Ling Wang, Yuan Li, Qin Ma, Yong Liu, Yuan-yi Rui, Ping Xue, Zong-guang Zhou. Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis[J]. Journal of Zhejiang University Science B, 2011, 12(12): 1034-1040.
@article{title="Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis",
author="Ling Wang, Yuan Li, Qin Ma, Yong Liu, Yuan-yi Rui, Ping Xue, Zong-guang Zhou",
journal="Journal of Zhejiang University Science B",
volume="12",
number="12",
pages="1034-1040",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000406"
}
%0 Journal Article
%T Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis
%A Ling Wang
%A Yuan Li
%A Qin Ma
%A Yong Liu
%A Yuan-yi Rui
%A Ping Xue
%A Zong-guang Zhou
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 12
%P 1034-1040
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000406
TY - JOUR
T1 - Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis
A1 - Ling Wang
A1 - Yuan Li
A1 - Qin Ma
A1 - Yong Liu
A1 - Yuan-yi Rui
A1 - Ping Xue
A1 - Zong-guang Zhou
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 12
SP - 1034
EP - 1040
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000406
Abstract: Objective: In this paper, we investigated the effect of the traditional Chinese medicine chaiqin Chengqi Decoction (CQCQD) on serum cytokines in acute pancreatitis (AP) patients. Methods: Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment. Control samples were collected from 20 healthy individuals. Serum proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and anti-inflammatory cytokines IL-10 and IL-1β receptor antagonist (IL-1ra) were examined using the Luminex 100 system. Results: Within the first 48 h of AP onset, IL-6 and IL-1ra levels in severe AP (SAP) patients were significantly higher than those in mild AP (MAP) patients, but IL-10 levels in SAP patients were significantly lower than those in MAP patients. Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment (P<0.05), especially in SAP patients (n=25 of 36, P<0.05). The hospitalization time of SAP patients was shortened significantly when serum IL-6 decreased after CQCQD treatment (P<0.05). Conclusions: CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients.
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