Full Text:   <1410>

CLC number: 

On-line Access: 2021-08-05

Received: 2020-11-15

Revision Accepted: 2021-06-04

Crosschecked: 0000-00-00

Cited: 0

Clicked: 1724

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2021 Vol.4 No.4 P.717-734

http://doi.org/10.1007/s42242-021-00142-7


Recent advances in the development of in vitro liver models for hepatotoxicity testing


Author(s):  Siming Lu, Jingwei Zhang, Sha Lin, Danfeng Zheng, Yan Shen, Jiale Qin, Yangyang Li, Shuqi Wang

Affiliation(s):  Department of Laboratory Medicine, The First Afliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   11526010@zju.edu.cn, shuqi@zju.edu.cn

Key Words:  Liver injury, Drug toxicity, 3D cultureIn vitro model


Share this article to: More

Siming Lu, Jingwei Zhang, Sha Lin, Danfeng Zheng, Yan Shen, Jiale Qin, Yangyang Li, Shuqi Wang . Recent advances in the development of in vitro liver models for hepatotoxicity testing[J]. Journal of Zhejiang University Science D, 2021, 4(4): 717-734.

@article{title="Recent advances in the development of in vitro liver models for hepatotoxicity testing",
author="Siming Lu, Jingwei Zhang, Sha Lin, Danfeng Zheng, Yan Shen, Jiale Qin, Yangyang Li, Shuqi Wang ",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="717-734",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00142-7"
}

%0 Journal Article
%T Recent advances in the development of in vitro liver models for hepatotoxicity testing
%A Siming Lu
%A Jingwei Zhang
%A Sha Lin
%A Danfeng Zheng
%A Yan Shen
%A Jiale Qin
%A Yangyang Li
%A Shuqi Wang
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 717-734
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00142-7

TY - JOUR
T1 - Recent advances in the development of in vitro liver models for hepatotoxicity testing
A1 - Siming Lu
A1 - Jingwei Zhang
A1 - Sha Lin
A1 - Danfeng Zheng
A1 - Yan Shen
A1 - Jiale Qin
A1 - Yangyang Li
A1 - Shuqi Wang
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 717
EP - 734
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00142-7


Abstract: 
liver injury is a common cause of drug approval withdrawal during drug development, pre-clinical research, and clinical treatment. If not properly treated, patients with severe liver injury can sufer from acute liver failure or even death. Thus, utilization of the convenient in vitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is vital for drug development and safe personalized medication. Biomaterials (e.g., hydrogels, nanofbers, decellularized liver matrix) and bioengineering technologies (e.g., microarrays, micropatterns, 3D printing, and microfuidics) have been applied for in vitro hepatotoxicity assessment models. This review summarizes the structure and functions of the liver as well as the components of in vitro hepatotoxicity assessment models. In addition, it highlights the latest advances in developing hepatotoxicity models with the ultimate goal of further clinical translation.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2023 Journal of Zhejiang University-SCIENCE