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Bio-Design and Manufacturing  2021 Vol.4 No.4 P.717-734

http://doi.org/10.1007/s42242-021-00142-7


Recent advances in the development of in vitro liver models for hepatotoxicity testing


Author(s):  Siming Lu, Jingwei Zhang, Sha Lin, Danfeng Zheng, Yan Shen, Jiale Qin, Yangyang Li, Shuqi Wang

Affiliation(s):  Department of Laboratory Medicine, The First Afliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   11526010@zju.edu.cn, shuqi@zju.edu.cn

Key Words:  Liver injury, Drug toxicity, 3D cultureIn vitro model


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Siming Lu, Jingwei Zhang, Sha Lin, Danfeng Zheng, Yan Shen, Jiale Qin, Yangyang Li, Shuqi Wang . Recent advances in the development of in vitro liver models for hepatotoxicity testing[J]. Journal of Zhejiang University Science D, 2021, 4(4): 717-734.

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publisher="Zhejiang University Press & Springer",
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Abstract: 
liver injury is a common cause of drug approval withdrawal during drug development, pre-clinical research, and clinical treatment. If not properly treated, patients with severe liver injury can sufer from acute liver failure or even death. Thus, utilization of the convenient in vitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is vital for drug development and safe personalized medication. Biomaterials (e.g., hydrogels, nanofbers, decellularized liver matrix) and bioengineering technologies (e.g., microarrays, micropatterns, 3D printing, and microfuidics) have been applied for in vitro hepatotoxicity assessment models. This review summarizes the structure and functions of the liver as well as the components of in vitro hepatotoxicity assessment models. In addition, it highlights the latest advances in developing hepatotoxicity models with the ultimate goal of further clinical translation.

浙大一院陆思铭等 | 体外肝毒性模型的研究进展

本综述论文聚焦体外肝毒性模型的研究进展。肝损伤是药物开发、临床前研究和临床治疗中药物被召回的常见原因。肝损伤患者如果没有得到适当治疗,会因此急性肝功能衰竭甚至死亡。因此,利用方便的体外肝毒性评估模型进行早期药物诱导的肝毒性检测,对于药物开发和个性化药物治疗至关重要。生物材料(例如水凝胶、纳米纤维和脱细胞肝脏基质)和生物工程技术(例如微阵列、3D打印和微流体技术)已应用于体外肝毒性评估模型研发。本综述总结了肝脏的结构和功能,以及体外肝毒性评估模型的分类。另外,本文突出介绍了肝毒性模型的最新进展及其临床转化。

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