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Bio-Design and Manufacturing  2023 Vol.6 No.6 P.646-660

http://doi.org/10.1007/s42242-023-00255-1


Design and realization of lung organoid cultures for COVID-19 applications


Author(s):  Bing Ren, Tryanni R. Chiaravalloti, Nadine L. Belony, Diana I. Romero, Wenxuan Chai, Christopher Leon, Lizi Wu, Nazarius S. Lamango, Ite A. Offringa & Yong Huang

Affiliation(s):  Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611, USA; more

Corresponding email(s):   yongh@ufl.edu

Key Words:  Lung organoid, COVID-19, Self-assembled organoid, Engineered organoid


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Bing Ren, Tryanni R. Chiaravalloti, Nadine L. Belony, Diana I. Romero, Wenxuan Chai, Christopher Leon, Lizi Wu, Nazarius S. Lamango, Ite A. Offringa & Yong Huang. Design and realization of lung organoid cultures for COVID-19 applications[J]. Journal of Zhejiang University Science D, 2023, 6(6): 646-660.

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Abstract: 
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally and threatens public health. Advanced in vitro models that recapitulate the architecture and functioning of specific tissues and organs are in high demand for COVID-19-related pathology studies and drug screening. Since three-dimensional in vitro cultures, such as self-assembled and engineered organoid cultures, surpass conventional two-dimensional cultures and animal models with respect to increased cellular complexity, an environment more relevant to humans, and reduced cost, they are promising platforms for understanding viral pathogenesis and developing new therapeutics. This review highlights the recent advances in self-assembled and engineered organoid technologies that are used for COVID-19 studies. The challenges and future perspectives are also discussed.

佛罗里达大学Yong Huang等 | 面向COVID-19的肺类器官的设计与实现

本综述论文聚焦面向COVID-19的肺类器官的设计与实现。新冠疫情(COVID-19)在全球蔓延并威胁到公共卫生安全。能够表现特定组织和器官的结构和功能的先进体外模型对于 COVID-19 相关病理学研究和药物筛查的需求量很大。三维体外培养组,如自组装和组织工程类器官培养组,在增加细胞复杂性、构建人体内更类似的环境和降低成本方面,均超越了传统的二维培养和动物模型,因此它们是了解病毒发病机制和开发新疗法的有前途的平台。本综述重点介绍了用于COVID-19研究的自组装和工程类器官技术的最新进展,并讨论了其挑战和未来前景。

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