Similar articles

Abstract: Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The literature search yielded 448 studies, in which 10 case-control studies including 1694 cases and 1456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89–1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09–1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the chinese population.

[1]Agellon, L.B., Quinet, E.M., Gillette, T.G., Drayna, D.T., Brown, M.L., Tall, A.R., 1990. Organization of the human cholesteryl ester transfer protein gene. Biochemistry, 29(6):1372-1376.

[2]Barter, P.J., Rye, K., 2001. Cholesteryl ester transfer protein, high density lipoprotein and arterial disease. Curr. Opin. Lipidol., 12(4):377-382.

[3]Barter, P.J., Brewer, H.B., Chapman, M.J., Hennekens, C.H., Rader, D.J., Tall, A.R., 2003. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 23(2):160-167.

[4]Boekholdt, S.M., Sacks, F.M., Jukema, J.W., Shepherd, J., Freeman, D.J., McMahon, A.D., Cambien, F., Nicaud, V., de Grooth, G.J., Talmud, P.J., et al., 2005. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13 677 subjects. Circulation, 111(3):278-287.

[5]Brousseau, M.E., O′Connor, J.J., Ordovas, J.M., Collins, D., Otvos, J.D., Massov, T., McNamara, J.R., Rubins, H.B., Robins, S.J., Schaefer, E.J., 2002. Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol Intervention Trial. Arterioscler. Thromb. Vasc. Biol., 22(7):1148-1154.

[6]Bu, X., Warden, C.H., Xia, Y.R., de Meester, C., Puppione, D.L., Teruya, S., Lokensgard, B., Daneshmand, S., Brown, J., Gray, R.J., 1994. Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci. Hum. Genet., 93(6):639-648.

[7]Corbex, M., Poirier, O., Fumeron, F., Betoulle, D., Evans, A., Ruidavets, J.B., Arveiler, D., Luc, G., Tiret, L., Cambien, F., 2000. Extensive association analysis between the CETP gene and coronary heart disease phenotypes reveals several putative functional polymorphisms and gene-environment interaction. Genet. Epidemiol., 19(1):64-80.

[8]Cuchel, M., Wolfe, M.L., de Lemos, A.S., Rader, D.J., 2002. The frequency of the cholesteryl ester transfer protein TaqI B2 allele is lower in African Americans than in Caucasians. Atherosclerosis, 163(1):169-174.

[9]Dullaart, R.P., Hoogenberg, K., Riemens, S.C., Groener, J.E., van Tol, A., Sluiter, W.J., Stulp, B.K., 1997. Cholesterol ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes. Diabetes, 46(12):2082-2087.

[10]Freeman, D.J., Griffin, B.A., Holmes, A.P., Lindsay, G.M., Gaffney, D., Packard, C.J., Shepherd, J., 1994. Regulation of plasma HDL cholesterol and subfraction distribution by genetic and invironmental factors. Association between the Taq1B RFLP in the CETP gene. Arterioscler. Thromb. Vasc. Biol., 14(3):336-344.

[11]Goto, A., Sasai, K., Suzuki, S., Fukutomi, T., Ito, S., Matsushita, T., Okamoto, M., Suzuki, T., Itoh, M., Okumura-Noji, K., et al., 2001. Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography. Atherosclerosis, 159(1):153-163.

[12]Groener, J.E., Pelton, R.W., Kostner, G.M., 1986. Improved estimation of cholesterol ester transfer/exchange activity in serum or plasma. Clin. Chem., 32(2):283-286.

[13]Inazu, A., Koizumi, J., Mabuchi, H., 2000. Cholesteryl ester transfer protein and atherosclerosis. Curr. Opin. Lipidol., 11(4):389-396.

[14]Kauma, H., Savolainen, M.J., Heikkilä, R., Rantala, A.O., Lilja, M., Reunanen, A., Kesäniemi, Y.A., 1996. Sex difference in the regulation of plasma high density lipoprotein cholesterol by genetic and environmental factors. Hum. Genet., 97(2):156-162.

[15]Kuivenhoven, J.A., Jukema, J.W., Zwinderman, A.H., de Knijff, P., McPherson, R., Bruschke, A.V., Lie, K.I., Kastelein, J.J., 1998. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. New Engl. J. Med., 338(2):86-93.

[16]Li, J., Deng, B., Lv, L., Zhao, M., Zheng, L., 2007. The association of the cholesterol ester transfer protein TaqIB polymorphism with the plasma lipids in patients with acute coronary syndrome. J. Clin. Cardiol., 23(9):663-665 (in Chinese).

[17]Libby, P., 1995. Molecular bases of the acute coronary syndromes. Circulation, 91(11):2844-2850.

[18]Liu, S., Schmitz, C., Stampfer, M.J., Sacks, F., Hennekens, C.H., Lindpaintner, K., Ridker, P.M., 2002. A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men. Atherosclerosis, 161(2):469-474.

[19]Ordovas, J.M., Cupples, L.A., Corella, D., Otvos, J.D., Osgood, D., Martinez, A., Lahoz, C., Coltell, O., Wilson, P.W., Schaefer, E.J., 2000. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler. Thromb. Vasc. Biol., 20(5):1323-1329.

[20]Park, K.W., Choi, J.H., Kim, H.K., Oh, S., Chae, I.H., Kim, H.S., Oh, B.H., Lee, M.M., Park, Y.B., Choi, Y.S., 2003. The association of cholesteryl ester transfer protein polymorphism with high-density lipoprotein cholesterol and coronary artery disease in Koreans. Clin. Genet., 63(1):31-38.

[21]Qin, Q., Zhao, B., Geng, J., Li, Y., Cui, R., Mao, Y., Hui, R., 2004. The association of the lipoprotein lipase S447X and cholesteryl ester transfer protein TaqIB polymorphism with coronary heart disease. Chin. J. Cardiol., 32(6):522-525 (in Chinese).

[22]Tsai, M.Y., Johnson, C., Kao, W.H., Sharrett, A.R., Arends, V.L., Kronmal, R., Jenny, N.S., Jacobs, D.R., Arnett, D., O′Leary, D., et al., 2008. Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 200(2):359-367.

[23]Wang, W., Zhou, X., Liu, F., Hu, H., Han, D., 2004. Association of the TaqIB polymorphism and D442G mutation of cholesteryl ester transfer protein gene with coronary heart disease. Chin. J. Cardiol., 32(11):981-985 (in Chinese).

[24]Wang, Y., 2006. The Effects of Cholesterol Ester Transfer Protein Polymorphism on Plasma Lipids Level and Its Relationship with Type 2 Diabetes Mellitus and Coronary Heart Disease. MS Thesis, Peking Union Medical College, Beijing, China (in Chinese).

[25]Wu, J.H., Lee, Y.T., Hsu, H.C., Hsieh, L.L., 2001. Influence of CETP gene variation on plasma lipid levels and coronary heart disease: a survey in Taiwan. Atherosclerosis, 159(2):451-458.

[26]Yan, S., Zhu, Y., Cheng, S., Song, Y., Yan, X., Zhu, W., 2004. Relationship between coronary heart disease and TaqIB & Msp I polymorphisms of cholesteryl ester transfer protein gene in Han nationality. Chin. J. Lab. Med., 27(10):671-675 (in Chinese).

[27]Zhang, G., Jiang, Z., Sun, B., Lu, Y., Wen, Q., Zhuang, W., Wang, F., 2005. Relationship of TaqIB polymorphism in the cholesteryl ester transfer protein gene to coronary artery disease. Chin. J. Arterioscler., 13(1):88-90 (in Chinese).

[28]Zhang, Y., Geng, J., Qin, Q., Mao, Y., Cui, R., 2003. The effects of TaqIB polymorphism of cholesteryl ester transfer protein on coronary heart disease. Tianjin Med. J., 31(12):758-760 (in Chinese).

[29]Zhao, S., Li, H., Xiao, Z., Nie, Z., 2004. The effects of TaqIB polymorphism of cholesteryl ester transfer protein on plasma lipoprotein level. Chin. J. Cardiol., 32(9):816-818 (in Chinese).

[30]Zheng, K.Q., Zhang, S.Z., He, Y., Zhang, L., Zhang, K.L., Huang, D.J., Sun, Y., 2004. Association between cholesteryl ester transfer protein gene polymorphisms and variations in lipid levels in patients with coronary heart disease. Chin. Med. J. (Engl.), 117(9):1288-1292 (in Chinese).