Similar articles

Abstract: Objective: To explore the feasibility and clinical value of secondary sentinel lymph node (SSLN) tracing technique in radical gastrectomy for advanced gastric cancer (AGC). Methods: From January 2009 to June 2011, 247 patients who suffered from gastric angle cancer with metastasis in No. 3 group lymph nodes were divided randomly into groups A and B. Methylthioninium chloride was injected into the peripheral tissue of the metastatic No. 3 group lymph nodes of 138 patients in group A before tumor resections. SSLNs were traced and individual lymphadenectomies were carried out based on the biopsy results of the SSLNs. Standard D2 radical gastrectomies were carried out directly on 109 patients in group B. Postoperative follow-up and survival analysis were carried out for patients in both groups. Results: SSLNs were found in 114 (82.6%) patients in group A. Ninety of those patients (78.9%) demonstrated existing metastasis in SSLNs. According to Kaplan-Meier’s method, the postoperative 3-year cumulative survival rates were 63.5% and 47.5%, and the median survival time were 40 and 36 months for the patients of groups A and B, respectively (P<0.05). Conclusions: The SSLN tracing technique is feasible in radical gastrectomy for AGC. It gives surgeons important information about the terminal status of lymph node metastasis and provides some scientific basis for individual lymphadenectomy.

二级前哨淋巴结示踪技术：进展期胃癌根治术中淋巴结示踪新方法

[1]Chen, R., He, Q., Cui, J., et al., 2014. Lymph node metastasis in early gastric cancer. Chin. Med. J., 127(3):560-567.

[2]Chen, S.L., Iddings, D.M., Scheri, R.P., et al., 2006. Lymphatic mapping and sentinel node analysis: current concepts and applications. CA Cancer J. Clin., 56(5):292-309.

[3]Dong, L.F., Wang, L.B., Shen, J.G., et al., 2012. Sentinel lymph node biopsy predicts lymph node metastasis in early gastric cancer: a retrospective analysis. Dig. Surg., 29(2):124-129.

[4]Erman, A.B., Collar, R.M., Griffith, K.A., et al., 2012. Sentinel lymph node biopsy is accurate and prognostic in head and neck melanoma. Cancer, 118(4):1040-1047.

[5]Hirayama, R., Seshimo, A., Miyake, K., et al., 2014. Intraoperative diagnosis of lymph node metastasis by transcription-reverse transcription concerted reaction assay in gastric cancer. Int. J. Clin. Oncol., 19(3):473-478.

[6]Japanese Gastric Cancer Association, 2011. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer, 14(2):113-123.

[7]Lee, H.S., Lee, H.E., Park, D.J., et al., 2012. Precise pathologic examination decreases the false-negative rate of sentinel lymph node biopsy in gastric cancer. Ann. Surg. Oncol., 19(3):772-778.

[8]Miyashiro, I., Hiratsuka, M., Sasako, M., et al., 2014. High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302. Gastric Cancer, 17(2):316-323.

[9]Mochiki, E., Kuwano, H., Kamiyama, Y., et al., 2006. Sentinel lymph node mapping with technetium-99m colloidal rhenium sulfide in patients with gastric carcinoma. Am. J. Surg., 191(4):465-469.

[10]Shimazu, K., Noguchi, S., 2011. Sentinel lymph node biopsy before versus after neoadjuvant chemotherapy for breast cancer. Surg. Today, 41(3):311-316.

[11]Symeonidis, D., Koukoulis, G., Tepetes, K., 2014. Sentinel node navigation surgery in gastric cancer: current status. World J. Gastrointest. Surg., 6(6):88-93.

[12]Tangoku, A., Seike, J., Nakano, K., et al., 2007. Current status of sentinel lymph node navigation surgery in breast and gastrointestinal tract. J. Med. Invest., 54(1-2):1-18.

[13]Tóth, D., Kathy, S., Csoban, T., et al., 2012. Prospective comparative study of sentinel lymph node mapping in gastric cancer—submucosal versus subserosal marking method. Magy. Seb., 65(1):3-8.

[14]van der Zaag, E.S., Bouma, W.H., Peters, H.M., et al., 2012. Implications of sentinel lymph node mapping on nodal staging and prognosis in colorectal cancer. Colorectal Dis., 14(6):684-690.

[15]Wang, Z., Dong, Z.Y., Chen, J.Q., et al., 2012. Diagnostic value of sentinel lymph node biopsy in gastric cancer: a meta-analysis. Ann. Surg. Oncol., 19(5):1541-1550.