CLC number: R457.1
On-line Access: 2020-12-09
Received: 2020-09-25
Revision Accepted: 2020-10-22
Crosschecked: 2020-11-11
Cited: 0
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Wei-ling Xiang, Jing-jing Cheng, Lian-peng Wu, Bing-yu Chen, Wen-xin Li, Dan-ying Qiu, Wei Zhang, Fei-hang Ge, Dong Chen, Zhen Wang. Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China[J]. Journal of Zhejiang University Science B, 2020, 21(12): 955-960.
@article{title="Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China",
author="Wei-ling Xiang, Jing-jing Cheng, Lian-peng Wu, Bing-yu Chen, Wen-xin Li, Dan-ying Qiu, Wei Zhang, Fei-hang Ge, Dong Chen, Zhen Wang",
journal="Journal of Zhejiang University Science B",
volume="21",
number="12",
pages="955-960",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000593"
}
%0 Journal Article
%T Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China
%A Wei-ling Xiang
%A Jing-jing Cheng
%A Lian-peng Wu
%A Bing-yu Chen
%A Wen-xin Li
%A Dan-ying Qiu
%A Wei Zhang
%A Fei-hang Ge
%A Dong Chen
%A Zhen Wang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 12
%P 955-960
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000593
TY - JOUR
T1 - Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China
A1 - Wei-ling Xiang
A1 - Jing-jing Cheng
A1 - Lian-peng Wu
A1 - Bing-yu Chen
A1 - Wen-xin Li
A1 - Dan-ying Qiu
A1 - Wei Zhang
A1 - Fei-hang Ge
A1 - Dong Chen
A1 - Zhen Wang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 12
SP - 955
EP - 960
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000593
Abstract: coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first affected humans in China on December 31, 2019 (Shi et al., 2020). Coronaviruses generally cause mild, self-limiting upper respiratory tract infections in humans, such as the common cold, pneumonia, and gastroenteritis (To et al., 2013; Berry et al., 2015; Chan et al., 2015). According to the Report of the World Health Organization (WHO)-China Joint Mission on COVID-19 (WHO, 2020), the case fatality rate of COVID-19 increases with age, while the rate among males is higher than that among females (4.7% and 2.8%, respectively). Since an effective vaccine and specific anti-viral drugs are still under development, passive immunization using the convalescent plasma (CP) of recovered COVID-19 donors may offer a suitable therapeutic strategy for severely ill patients in the meantime. So far, several studies have shown therapeutic efficacy of CP transfusion in treating COVID-19 cases. A pilot study first reported that transfusion of CP with neutralizing antibody titers above 1:640 was well tolerated and could potentially improve clinical outcomes through neutralizing viremia in severe COVID-19 cases (Chen et al., 2020). Immunoglobulin G (IgG) and IgM are the most abundant and important antibodies in protecting the human body from viral attack (Arabi et al., 2015; Marano et al., 2016). Our study aimed to understand the aspects of plasma antibody titer levels in convalescent patients, as well as assessing the clinical characteristics of normal, severely ill, and critically ill patients, and thus provide a basis for guiding CP therapy. We also hoped to find indicators which could serve as a reference in predicting the progression of the disease.
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[18]List of electronic supplementary materials
[19]Fig. S1 Correlation between IgG/IgM titer and different laboratory indexes
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