CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 0
Clicked: 3050
Citations: Bibtex RefMan EndNote GB/T7714
Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis[J]. Journal of Zhejiang University Science B, 2022, 23(2): 158-163.
@article{title="Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis",
author="Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN",
journal="Journal of Zhejiang University Science B",
volume="23",
number="2",
pages="158-163",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100502"
}
%0 Journal Article
%T Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
%A Jie LUO
%A Zhimin SONG
%A Tao ZHANG
%A Ketan CHU
%A Jingyi LI
%A Jianhong ZHOU
%A Jun LIN
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 2
%P 158-163
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100502
TY - JOUR
T1 - Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
A1 - Jie LUO
A1 - Zhimin SONG
A1 - Tao ZHANG
A1 - Ketan CHU
A1 - Jingyi LI
A1 - Jianhong ZHOU
A1 - Jun LIN
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 2
SP - 158
EP - 163
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100502
Abstract: At present, endometriosis remains a worldwide health burden, with the main symptoms of dysmenorrhea, chronic pelvic pain, and infertility, markedly reducing the quality of life (
[1]AlnafakhRAA, AdisheshM, ButtonL, et al., 2019. Telomerase and telomeres in endometrial cancer. Front Oncol, 9:344.
[2]BozdagG, 2015. Recurrence of endometriosis: risk factors, mechanisms and biomarkers. Women’s Health, 11(5):693-699.
[3]BubendorfL, SauterG, MochH, et al., 1996. Ki67 labelling index: an independent predictor of progression in prostate cancer treated by radical prostatectomy. J Pathol, 178(4):437-441.
[4]CeccaroniM, BounousVE, ClariziaR, et al., 2019. Recurrent endometriosis: a battle against an unknown enemy. Eur J Contracept Reprod Health Care, 24(6):464-474.
[5]ChapronC, MarcellinL, BorgheseB, et al., 2019. Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol, 15(11):666-682.
[6]ChiangHJ, LinPY, HuangFJ, et al., 2015. The impact of previous ovarian surgery on ovarian reserve in patients with endometriosis. BMC Women’s Health, 15:74.
[7]de ZieglerD, BorgheseB, ChapronC, 2010. Endometriosis and infertility: pathophysiology and management. Lancet, 376(9742):730-738.
[8]DingL, ZhouYX, HeC, et al., 2020. Elevated CA125 levels are associated with adverse clinical outcomes in acute pancreatitis: a propensity score-matched study. Pancreatology, 20(5):789-794.
[9]GreeneAD, LangSA, KendziorskiJA, et al., 2016. Endometriosis: where are we and where are we going? Reproduction, 152(3):R63-R78.
[10]HanegeBY, ÇekıçSG, AtaB, 2019. Endometrioma and ovarian reserve: effects of endometriomata per se and its surgical treatment on the ovarian reserve. Facts Views Vis Obgyn, 11(2):151-157.
[11]HannenR, BartschJW, 2018. Essential roles of telomerase reverse transcriptase hTERT in cancer stemness and metastasis. FEBS Lett, 592(12):2023-2031.
[12]HuCJ, NiZH, LiBS, et al., 2017. hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation. Gut, 66(1):31-42.
[13]KajiyamaH, SuzukiS, YoshiharaM, et al., 2019. Endometriosis and cancer. Free Radic Biol Med, 133:186-192.
[14]KalaitzopoulosDR, MitsopoulouA, IliopoulouSM, et al., 2020. Association between endometriosis and gynecological cancers: a critical review of the literature. Arch Gynecol Obstet, 301(2):355-367.
[15]KogaK, TakamuraM, FujiiT, et al., 2015. Prevention of the recurrence of symptom and lesions after conservative surgery for endometriosis. Fertil Steril, 104(4):793-801.
[16]LaganàAS, GarzonS, GötteM, et al., 2019. The pathogenesis of endometriosis: molecular and cell biology insights. Int J Mol Sci, 20(22):5615.
[17]LiCH, WangCH, 2021. LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(8):633-646.
[18]LiLT, JiangG, ChenQ, et al., 2015. Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep, 11(3):1566-1572.
[19]LiXY, ChaoXP, LengJH, et al., 2019. Risk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women. J Ovarian Res, 12:79.
[20]LiY, LiRQ, OuyangNY, et al., 2019. Investigating the impact of local inflammation on granulosa cells and follicular development in women with ovarian endometriosis. Fertil Steril, 112(5):882-891.e1.
[21]LiuSP, XinWJ, TangXY, et al., 2020. LncRNA H19 overexpression in endometriosis and its utility as a novel biomarker for predicting recurrence. Reprod Sci, 27(9):1687-1697.
[22]McPeakAE, AllaireC, WilliamsC, et al., 2018. Pain catastrophizing and pain health-related quality-of-life in endometriosis. Clin J Pain, 34(4):349-356.
[23]MillerI, MinMW, YangC, et al., 2018. Ki67 is a graded rather than a binary marker of proliferation versus quiescence. Cell Rep, 24(5):1105-1112.e5.
[24]ParkJS, LeeJH, KimM, et al., 2009. Endometrium from women with endometriosis shows increased proliferation activity. Fertil Steril, 92(4):1246-1249.
[25]PooleJC, AndrewsLG, TollefsbolTO, 2001. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene, 269(1-2):1-12.
[26]RollaE, 2019. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000Research, 8:529.
[27]SakamotoY, HaradaT, HorieS, et al., 2003. Tumor necrosis factor-α-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-κB activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression. J Clin Endocrinol Metab, 88(2):730-735.
[28]SocolovR, SocolovD, SindilarA, et al., 2017. An update on the biological markers of endometriosis. Minerva Ginecol, 69(5):462-467.
[29]TurkDC, 2002. Clinical effectiveness and cost-effectiveness of treatments for patients with chronic pain. Clin J Pain, 18(6):355-365.
[30]VercelliniP, ViganòP, SomiglianaE, et al., 2014. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol, 10(5):261-275.
Open peer comments: Debate/Discuss/Question/Opinion
<1>