Similar articles

Abstract: Drinking culture has high significance in both China and the world, whether in the entertainment sector or in social occasions; according to the World Health Organization's 2018 Global Alcohol and Health Report, about 3 million people died from excessive drinking in 2016, accounting for 5.3% of the total global deaths that year. oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse (Snyder et al., 2017). scutellarin, a kind of flavonoid, is one of the main active ingredients extracted from breviscapine. It exerts anti-inflammatory, antioxidant, and vasodilation effects, and has been used to treat cardiovascular diseases and alcoholic liver injury. Although scutellarin can effectively alleviate multi-target organ injury induced by different forms of stimulation, its protective effect on alcoholic brain injury has not been well-defined. Therefore, the present study established an acute alcohol mice brain injury model to explore the effect of scutellarin on acute alcoholic brain injury. The study was carried out based on the targets of oxidative stress and inflammation, which is of great significance for the targeted therapy of clinical alcohol diseases.

灯盏花乙素对小鼠急性酒精性脑损伤的改善作用

[1]Alfonso-LoechesS, Ureña-PeraltaJR, Morillo-BarguesMJ, et al., 2014. Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells. Front Cell Neurosci, 8:216.

[2]AmenY, SherifAE, ShawkyNM, et al., 2020. Grape-leaf extract attenuates alcohol-induced liver injury via interference with NF‍-‍κB signaling pathway. Biomolecules, 10(4):558.

[3]BaluchnejadmojaradT, ZeinaliH, RoghaniM, 2018. Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: insights into underlying mechanisms. Int Immunopharmacol, 54:311-319.

[4]FanRH, ZhangY, BotchwayBOA, et al., 2021. Resveratrol can attenuate astrocyte activation to treat spinal cord injury by inhibiting inflammatory responses. Mol Neurobiol, 58:5799-5813.

[5]HathroubiS, Loera-MuroA, Guerrero-BarreraAL, et al., 2018. Actinobacillus pleuropneumoniae biofilms: role in pathogenicity and potential impact for vaccination development. Anim Health Res Rev, 19(1):17-30.

[6]LiXY, FangP, MaiJT, et al., 2013. Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J Hematol Oncol, 6:19.

[7]LiuFE, LiL, LuW, et al., 2020. Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways. Int Immunopharmacol, 78:105954.

[8]Mas-BarguesC, EscriváC, DromantM, et al., 2021. Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease. Arch Biochem Biophys, 709:108941.

[9]SnyderB, ShellB, CunninghamJT, et al., 2017. Chronic intermittent hypoxia induces oxidative stress and inflammation in brain regions associated with early-stage neurodegeneration. Physiol Rep, 5(9):e13258.

[10]WangC, LiYF, GaoSC, et al., 2015. Breviscapine injection improves the therapeutic effect of Western medicine on angina pectoris patients. PLoS ONE, 10(6):e0129969.

[11]WangJN, TanJY, LuoJH, et al., 2017. Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. J Nanobiotechnol, 15:18.

[12]WangWH, LiJY, LiF, et al., 2019. Scutellarin suppresses cartilage destruction in osteoarthritis mouse model by inhibiting the NF-‍κB and PI3K/AKT signaling pathways. Int Immunopharmacol, 77:105928.

[13]WuHY, JiaL, 2019. Scutellarin attenuates hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and oxidative stress through regulating Keap1/Nrf2/ARE signaling. Biosci Rep, 39(11):BSR20192501.

[14]XuXX, ZhangW, ZhangP, et al., 2013. Superior renoprotective effects of the combination of breviscapine with enalapril and its mechanism in diabetic rats. Phytomedicine, 20(10):820-827.

[15]YuY, TianZQ, LiangL, et al., 2019. Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy. Cell Biosci, 9:80.

[16]ZhangY, WeiGK, DiZY, et al., 2014. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway. Biochem Biophys Res Commun, 452(3):450-456.

[17]ZhengZ, ShenY, XiaL, et al., 2020. Glucocorticoid and breviscapine combination therapy versus glucocorticoid alone on sudden sensorineural hearing loss in patients with different audiometric curves. Adv Ther, 37(12):4959-4968.