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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.10 P.1245-1248


Effects of vanadate on the activities of mice glucokinase and hexokinase

Author(s):  XU Ming-zhi, ZHANG Ai-zhen, LI Xiang-rong, XU Wei, SHEN Ling-wei

Affiliation(s):  Department of Endocrinology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   xu921@21cn.com

Key Words:  Sodium metavanadate (SMV), Glucokinase, Hexokinase, Blood glucose, Insulin

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XU Ming-zhi, ZHANG Ai-zhen, LI Xiang-rong, XU Wei, SHEN Ling-wei. Effects of vanadate on the activities of mice glucokinase and hexokinase[J]. Journal of Zhejiang University Science A, 2004, 5(10): 1245-1248.

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publisher="Zhejiang University Press & Springer",

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%T Effects of vanadate on the activities of mice glucokinase and hexokinase
%A XU Ming-zhi
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%A LI Xiang-rong
%A XU Wei
%A SHEN Ling-wei
%J Journal of Zhejiang University SCIENCE A
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.1245

T1 - Effects of vanadate on the activities of mice glucokinase and hexokinase
A1 - XU Ming-zhi
A1 - ZHANG Ai-zhen
A1 - LI Xiang-rong
A1 - XU Wei
A1 - SHEN Ling-wei
J0 - Journal of Zhejiang University Science A
VL - 5
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SP - 1245
EP - 1248
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2004.1245

This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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