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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.10 P.1245-1248

http://doi.org/10.1631/jzus.2004.1245


Effects of vanadate on the activities of mice glucokinase and hexokinase


Author(s):  XU Ming-zhi, ZHANG Ai-zhen, LI Xiang-rong, XU Wei, SHEN Ling-wei

Affiliation(s):  Department of Endocrinology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   xu921@21cn.com

Key Words:  Sodium metavanadate (SMV), Glucokinase, Hexokinase, Blood glucose, Insulin


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XU Ming-zhi, ZHANG Ai-zhen, LI Xiang-rong, XU Wei, SHEN Ling-wei. Effects of vanadate on the activities of mice glucokinase and hexokinase[J]. Journal of Zhejiang University Science A, 2004, 5(10): 1245-1248.

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author="XU Ming-zhi, ZHANG Ai-zhen, LI Xiang-rong, XU Wei, SHEN Ling-wei",
journal="Journal of Zhejiang University Science A",
volume="5",
number="10",
pages="1245-1248",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.1245"
}

%0 Journal Article
%T Effects of vanadate on the activities of mice glucokinase and hexokinase
%A XU Ming-zhi
%A ZHANG Ai-zhen
%A LI Xiang-rong
%A XU Wei
%A SHEN Ling-wei
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 10
%P 1245-1248
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.1245

TY - JOUR
T1 - Effects of vanadate on the activities of mice glucokinase and hexokinase
A1 - XU Ming-zhi
A1 - ZHANG Ai-zhen
A1 - LI Xiang-rong
A1 - XU Wei
A1 - SHEN Ling-wei
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 10
SP - 1245
EP - 1248
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.1245


Abstract: 
This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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[2] Gupta, D., Raju, J., Prakash, J., Baquer, N.Z., 1999. Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: effect of insulin and vanadate. Diabetes Research & Clinical Practice, 46(1):1-7.

[3] Lucia, M., Maria, A., Angeles, M., Carmen, A., Fernando, E., 2002. Effects of chronic undernutrition on glucose uptake and glucose transporter proteins in rat heart. Endocrinology, 143:4295-4303.

[4] Mosseri, R., Waner, T., Shefi, M., Shafrir, E., Meyerovitch, J., 2000. Gluconeogenesis in non-obese diabetic (NOD) mice: in vivo effects of vandadate treatment on hepatic glucose-6-phoshatase and phosphoenolpyruvate carboxykinase. Metabolism, 49(3):321-325.

[5] Poucheret, P., Verma, S., Grynpas, M.D., Mcneill, J.H., 1998. Vanadium and diabetes. Molecular and Cellular Bio-chemistry, 188(1-2):73-80.

[6] Rondinone, C., Smith, U., 2000. Insulin resistance in fat cells from obese Zucker rats(evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4. Mol Cell Biochem, 206(1-2):7-16.

[7] Satish, P., Pamela, A., Graham, R., Stefano, F., Mario, P., Sara, C.K., George, T., Calum, S., 2002. Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity. J. Biol. Chem., 277:9889-9895.

[8] Shechter, Y., 1990. Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes. Diabetes, 39(1):1-5.

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