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MDM2/X mediate reduced apoptosis in plateau zokor: a mechanism of high-altitude adaptation
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Mengchen ZHANG1,2, Yi LI1,2, Huiqi LIN3, Tianfu YU1,2, Fangyuan XIA1,2, Mahanand CHATOO1,2, Kexin LI4, Honghao YU5, Eviatar NEVO6, Jizeng DU2, Yang ZHAO3, Xuequn CHEN1,2. MDM2/X mediate reduced apoptosis in plateau zokor: a mechanism of high-altitude adaptation[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="MDM2/X mediate reduced apoptosis in plateau zokor:
a mechanism of high-altitude adaptation",
author="Mengchen ZHANG1,2, Yi LI1,2, Huiqi LIN3, Tianfu YU1,2, Fangyuan XIA1,2, Mahanand CHATOO1,2, Kexin LI4, Honghao YU5, Eviatar NEVO6, Jizeng DU2, Yang ZHAO3, Xuequn CHEN1,2",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500281"
}
%0 Journal Article
%T MDM2/X mediate reduced apoptosis in plateau zokor:
a mechanism of high-altitude adaptation
%A Mengchen ZHANG1
%A 2
%A Yi LI1
%A 2
%A Huiqi LIN3
%A Tianfu YU1
%A 2
%A Fangyuan XIA1
%A 2
%A Mahanand CHATOO1
%A 2
%A Kexin LI4
%A Honghao YU5
%A Eviatar NEVO6
%A Jizeng DU2
%A Yang ZHAO3
%A Xuequn CHEN1
%A 2
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500281
TY - JOUR
T1 - MDM2/X mediate reduced apoptosis in plateau zokor:
a mechanism of high-altitude adaptation
A1 - Mengchen ZHANG1
A1 - 2
A1 - Yi LI1
A1 - 2
A1 - Huiqi LIN3
A1 - Tianfu YU1
A1 - 2
A1 - Fangyuan XIA1
A1 - 2
A1 - Mahanand CHATOO1
A1 - 2
A1 - Kexin LI4
A1 - Honghao YU5
A1 - Eviatar NEVO6
A1 - Jizeng DU2
A1 - Yang ZHAO3
A1 - Xuequn CHEN1
A1 - 2
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500281
Abstract: MDM2 (Murine double minute 2) and MDMX (Murine double minute 4) are critical for the regulation of p53 function and apoptosis. This study compares the MDM2/x gene sequences and functional variations of subterranean zokors in high plateaus and loess plateaus. The findings reveal the molecular mechanisms behind how these species' MDM2/X variations drive adaptation to extremely high-altitude conditions, including low oxygen, cold temperatures, and perpetual darkness in underground environments. We cloned and analyzed MDM2/x sequences from two distinct ecological groups of subterranean rodents, Myospalax baileyi (M.b., plateau zokor) and Myospalax cansus (M.c., Gansu zokor), and reconstructed phylogenetic trees for a series of rodents and mammals of subterranean species and the aboveground lab rat, as well as humans. We found that MDM2/X of M.b. and M.c. are involved in the low apoptosis rate dependent on p53, and the variations of phosphorylation sites in the C-terminal of MDM2 contribute to upregulation of p53 transcription and protein expression. We propose that gene evolutionary mechanisms enable survival under these severe combined pressures, and believe that our findings provide critical insight into how genetic modifications drive physiological resilience in Earth's most challenging ecosystems.
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