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CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes
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Yuta YANG1*, Shaoli ZHANG1*, Lei CHEN1, Yunan HE1, Enhui JIANG1, Chuanying PAN1, Yang LI1, Chuzhao LEI1, Jiyao WU2, Xianyong LAN1. CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes",
author="Yuta YANG1*, Shaoli ZHANG1*, Lei CHEN1, Yunan HE1, Enhui JIANG1, Chuanying PAN1, Yang LI1, Chuzhao LEI1, Jiyao WU2, Xianyong LAN1",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500442"
}
%0 Journal Article
%T CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes
%A Yuta YANG1*
%A Shaoli ZHANG1*
%A Lei CHEN1
%A Yunan HE1
%A Enhui JIANG1
%A Chuanying PAN1
%A Yang LI1
%A Chuzhao LEI1
%A Jiyao WU2
%A Xianyong LAN1
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500442
TY - JOUR
T1 - CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes
A1 - Yuta YANG1*
A1 - Shaoli ZHANG1*
A1 - Lei CHEN1
A1 - Yunan HE1
A1 - Enhui JIANG1
A1 - Chuanying PAN1
A1 - Yang LI1
A1 - Chuzhao LEI1
A1 - Jiyao WU2
A1 - Xianyong LAN1
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500442
Abstract: Fat deposition is a key factor influencing beef quality. Therefore, understanding the regulatory mechanisms of adipogenesis is crucial for improving meat production traits in cattle. Circular RNAs (circRNAs) have emerged as important post-transcriptional regulators in various biological processes, including adipocyte differentiation. In our study, circMED17 was identified as a stable, nuclear-localized circRNA derived from exons 2 and 3 of the MED17 gene, with its expression markedly upregulated during bovine preadipocyte differentiation, suggesting its potential role in adipogenesis. Functional analyses revealed that circMED17 inhibits preadipocyte proliferation and apoptosis while promoting differentiation and lipid accumulation. Mechanistically, circMED17 exerts dual regulatory effects by sponging miR-146b as a competing endogenous RNA (ceRNA) and by directly interacting with the transcription factor GATA2. Importantly, the in vivo overexpression of circMED17 in obese mice increased subcutaneous fat deposition, confirming its pro-adipogenic role. Collectively, the findings reveal a previously unreported dual mechanism of circMED17 in bovine adipogenesis and highlight its potential as a molecular target for improving beef quality through genetic and breeding strategies.
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