Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases
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Jingbo LAI1,2, Ruolang PAN3, Jing ZHENG1, Ye CHEN1,2. Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases",
author="Jingbo LAI1,2, Ruolang PAN3, Jing ZHENG1, Ye CHEN1,2",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500699"
}
%0 Journal Article
%T Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases
%A Jingbo LAI1
%A 2
%A Ruolang PAN3
%A Jing ZHENG1
%A Ye CHEN1
%A 2
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500699
TY - JOUR
T1 - Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases
A1 - Jingbo LAI1
A1 - 2
A1 - Ruolang PAN3
A1 - Jing ZHENG1
A1 - Ye CHEN1
A1 - 2
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP - 0
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500699
Abstract: The bidirectional relationship between pathological microenvironments and mesenchymal stem/stromal cells (MSCs) is known as a pivotal factor influencing the progression of bone-related disease and therapeutic outcomes. MSCs, characterized by their remarkable plasticity and excellent immunomodulatory abilities, play central roles in various physiological and pathological processes, especially in bone regeneration and repair. Under pathological conditions, such as osteoarthritis, osteoporosis, or bone tumors, the tissue microenvironment can significantly alter MSC behavior, leading to impaired differentiation, dysregulated immune responses, or abnormal tissue remodeling. This dynamic relationship is regulated by diverse molecular signals, where long non-coding RNAs (lncRNAs) emerge as critical regulators of MSC biology. LncRNAs influence MSC differentiation, immunomodulatory functions, and responses to microenvironmental cues through diverse molecular mechanisms. The systematic review elucidates the roles of various lncRNAs involved in different aspects of MSC biology under pathological conditions and their potential as therapeutic targets or biomarkers for bone-related disorders.
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