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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2022-02-21
Cited: 0
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4D printing of core–shell hydrogel capsules for smart controlled drug release
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Shuo Zu, Zhihui Zhang, Qingping Liu, Zhenguo Wang, Zhengyi Song, Yunting Guo, Yuanzhu Xin & Shuang Zhang . 4D printing of core–shell hydrogel capsules for smart controlled drug release[J]. Journal of Zhejiang University Science D, 2022, 5(2): 294-304.
@article{title="4D printing of core–shell hydrogel capsules for smart controlled drug release",
author="Shuo Zu, Zhihui Zhang, Qingping Liu, Zhenguo Wang, Zhengyi Song, Yunting Guo, Yuanzhu Xin & Shuang Zhang ",
journal="Journal of Zhejiang University Science D",
volume="5",
number="2",
pages="294-304",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00175-y"
}
%0 Journal Article
%T 4D printing of core–shell hydrogel capsules for smart controlled drug release
%A Shuo Zu
%A Zhihui Zhang
%A Qingping Liu
%A Zhenguo Wang
%A Zhengyi Song
%A Yunting Guo
%A Yuanzhu Xin & Shuang Zhang
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 2
%P 294-304
%@ 1869-1951
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00175-y
TY - JOUR
T1 - 4D printing of core–shell hydrogel capsules for smart controlled drug release
A1 - Shuo Zu
A1 - Zhihui Zhang
A1 - Qingping Liu
A1 - Zhenguo Wang
A1 - Zhengyi Song
A1 - Yunting Guo
A1 - Yuanzhu Xin & Shuang Zhang
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 2
SP - 294
EP - 304
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00175-y
Abstract: personalized drugs, as well as disease-specific and condition-dependent drug release, have been highly desired in drug delivery systems for effective and safe therapies. Four-dimensional (4D) printing, as a newly emerging technique to develop drug capsules, displays unique advantages that can autonomously control drug release according to the actual physiological circumstances. Herein, core–shell structured hydrogel capsules were developed using a multimaterial extrusion-based 4D printing method, which consists of a model drug as the core and UV cross-linked poly(N-isopropylacrylamide) (PNIPAM) hydrogel as the shell. Owing to the lower critical solution temperature (LCST)-induced shrinking/swelling properties, the prepared PNIPAM hydrogel capsules showed temperature-responsive drug release along with the topography changes in the cross-linked PNIPAM network. The in vitro drug release test confirmed that the PNIPAM hydrogel capsules can autonomously control their drug release behaviors according to changes in ambient temperature. Moreover, the increased shell thickness of these capsules causes an obvious reduction in drug release rate, distinctly indicating that the drug release behavior can be well adjusted by setting the shell thickness of the capsules. The proposed 4D printing strategy pioneers the paradigm of smart drug release by showing great potential in the smart controlled release of drugs and macromolecular active agents.
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