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Received: 2023-10-17
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Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review
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F. Melo-Fonseca, O. Carvalho, M. Gasik, G. Miranda & F. S. Silva . Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review[J]. Journal of Zhejiang University Science D, 2023, 6(3): 340-371.
@article{title="Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review",
author="F. Melo-Fonseca, O. Carvalho, M. Gasik, G. Miranda & F. S. Silva ",
journal="Journal of Zhejiang University Science D",
volume="6",
number="3",
pages="340-371",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00232-8"
}
%0 Journal Article
%T Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review
%A F. Melo-Fonseca
%A O. Carvalho
%A M. Gasik
%A G. Miranda & F. S. Silva
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 3
%P 340-371
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00232-8
TY - JOUR
T1 - Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review
A1 - F. Melo-Fonseca
A1 - O. Carvalho
A1 - M. Gasik
A1 - G. Miranda & F. S. Silva
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 3
SP - 340
EP - 371
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00232-8
Abstract: Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human body. To more closely mimic the complex physiological environment, research has moved from two-dimensional (2D) culture systems to more sophisticated three-dimensional (3D) dynamic cultures. Unlike bioreactors or microfluidic-based culture models, cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses, such as tensile or compressive. This review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to improvement. These are the features which could be focused on to perform, in the future, more reliable and accurate mechanobiology studies.
Open peer comments: Debate/Discuss/Question/Opinion
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