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Mano Govindharaj, Noura Al Hashimi, Soja Saghar Soman, Jiarui Zhou, Safeeya AlAwadhi, Sanjairaj Vijayavenkataraman. 3D-bioprinted tri-layered cellulose/collagen-based drug-eluting fillers for the treatment of deep tunneling wounds[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="3D-bioprinted tri-layered cellulose/collagen-based drug-eluting fillers for the
treatment of deep tunneling wounds",
author="Mano Govindharaj, Noura Al Hashimi, Soja Saghar Soman, Jiarui Zhou, Safeeya AlAwadhi, Sanjairaj Vijayavenkataraman",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00305-2"
}
%0 Journal Article
%T 3D-bioprinted tri-layered cellulose/collagen-based drug-eluting fillers for the
treatment of deep tunneling wounds
%A Mano Govindharaj
%A Noura Al Hashimi
%A Soja Saghar Soman
%A Jiarui Zhou
%A Safeeya AlAwadhi
%A Sanjairaj Vijayavenkataraman
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
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%@ 1869-1951
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00305-2
TY - JOUR
T1 - 3D-bioprinted tri-layered cellulose/collagen-based drug-eluting fillers for the
treatment of deep tunneling wounds
A1 - Mano Govindharaj
A1 - Noura Al Hashimi
A1 - Soja Saghar Soman
A1 - Jiarui Zhou
A1 - Safeeya AlAwadhi
A1 - Sanjairaj Vijayavenkataraman
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1869-1951
Y1 - 2016
PB - Zhejiang University Press & Springer
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DOI - 10.1007/s42242-024-00305-2
Abstract: tunneling wounds create passageways underneath the skin surface with varying sizes and shapes
and can have twists and turns, making their treatment extremely difficult. Available wound care
solutions only cater to superficial wounds, and untreated tunneling wounds pose major health
concerns. This study aims to fulfill this challenge by fabricating tunnel wound fillers (TWFs) made
of natural polymers that mimic the dermal extracellular matrix. In this study, cellulose microfibers
(CMFs) derived from banana stem and fish skin-derived collagen were used to formulate bio-inks
with varying CMF contents (25, 50, and 75 mg). Trilayered (CMFs, primary and secondary
collagen coatings), drug-eluting (Baneocin), and cell-laden (human mesenchymal stem cells)
TWFs were three-dimensional (3D)-printed and extensively characterized. CMFs showed the most
suitable rheological properties for 3D printing at 50 mg concentration. The Alamar blue data
showed significantly increased cell proliferation from Day 1 to Day 7, and scratch tests used to
evaluate in vitro wound healing revealed that the best coverage of the wound area was achieved
using CMFs in combination with collagen and alginate. Finally, the TWF showed promising
capability and tunability in terms of wound shape and size upon testing on a chicken tissue model.
The results demonstrate the tremendous potential of TWFs in treating deep tunneling wounds with
unique advantages, such as patient-specific customization, good wound exudate absorption capability while releasing wound healing drugs, and the inclusion of stem cells for accelerated
healing and tissue regeneration.
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