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Bio-Design and Manufacturing  2018 Vol.1 No.3 P.171-181

http://doi.org/10.1007/s42242-018-0017-y


Current advances in solid free-form techniques for osteochondral tissue engineering


Author(s):  João Bebiano Costa, Joana Silva-Correia, Rui Luís Reis, Joaquim Miguel Oliveira

Affiliation(s):  3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; more

Corresponding email(s):   miguel.oliveira@i3bs.uminho.pt

Key Words:  Solid free-form · Osteochondral · Tissue engineering · Scaffolds


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João Bebiano Costa, Joana Silva-Correia, Rui Luís Reis, Joaquim Miguel Oliveira. Current advances in solid free-form techniques for osteochondral tissue engineering[J]. Journal of Zhejiang University Science D, 2018, 1(3): 171-181.

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Abstract: 
Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds’ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro–macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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