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Received: 2010-09-04

Revision Accepted: 2011-07-26

Crosschecked: 2011-08-15

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.9 P.769-779


Digital design of scaffold for mandibular defect repair based on tissue engineering

Author(s):  Yun-feng Liu, Fu-dong Zhu, Xing-tao Dong, Wei Peng

Affiliation(s):  Key Laboratory of E & M (Zhejiang University of Technology), Ministry of Education & Zhejiang Province, Hangzhou 310032, China, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   liuyf76@126.com

Key Words:  Digital design, Mandibular defect, Scaffold, Tissue engineering

Yun-feng Liu, Fu-dong Zhu, Xing-tao Dong, Wei Peng. Digital design of scaffold for mandibular defect repair based on tissue engineering[J]. Journal of Zhejiang University Science B, 2011, 12(9): 769-779.

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%DOI 10.1631/jzus.B1000323

T1 - Digital design of scaffold for mandibular defect repair based on tissue engineering
A1 - Yun-feng Liu
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A1 - Xing-tao Dong
A1 - Wei Peng
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1000323

mandibular defect occurs more frequently in recent years, and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic flaws. tissue engineering, which is a hot research field of biomedical engineering, provides a new direction for mandibular defect repair. As the basis and key part of tissue engineering, scaffolds have been widely and deeply studied in regards to the basic theory, as well as the principle of biomaterial, structure, design, and fabrication method. However, little research is targeted at tissue regeneration for clinic repair operations. Since mandibular bone has a special structure, rather than uniform and regular structure in existing studies, a methodology based on tissue engineering is proposed for mandibular defect repair in this paper. Key steps regarding scaffold digital design, such as external shape design and internal microstructure design directly based on triangular meshes are discussed in detail. By analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping, the feasibility and effectiveness of the proposed methodology are properly verified. More works about mechanical and biological improvements need to be done to promote its clinical application in future.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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