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Bio-Design and Manufacturing  2021 Vol.4 No.3 P.568-595

http://doi.org/10.1007/s42242-020-00120-5


Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects


Author(s):  Tarun Agarwal, Valentina Onesto, Lallepak Lamboni, Aafreen Ansari, Tapas K. Maiti, Pooyan Makvandi, Massoud Vosough & Guang Yang

Affiliation(s):  Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India; more

Corresponding email(s):   tkmaiti@bt.iitkgp.ac.in, maititapask@gmail.com

Key Words:  Intestine tissue models, Microfabrication, Biophysicochemical and biomechanical cues, Coculture, Induced pluripotent stem cells


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Tarun Agarwal, Valentina Onesto, Lallepak Lamboni, Aafreen Ansari, Tapas K. Maiti, Pooyan Makvandi, Massoud Vosough & Guang Yang . Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects[J]. Journal of Zhejiang University Science D, 2021, 4(3): 568-595.

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author="Tarun Agarwal, Valentina Onesto, Lallepak Lamboni, Aafreen Ansari, Tapas K. Maiti, Pooyan Makvandi, Massoud Vosough & Guang Yang ",
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year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00120-5"
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Abstract: 
Conventional 2D intestinal models cannot precisely recapitulate biomimetic features in vitro and thus are unsuitable for various pharmacokinetic applications, development of disease models, and understanding the host-microbiome interactions. Thus, recently, efforts have been directed toward recreating in vitro models with intestine-associated unique 3D crypt-villus (for small intestine) or crypt-lumen (for large intestine) architectures. This review comprehensively delineates the current advancements in this research area in terms of the different microfabrication technologies (photolithography, laser ablation, and 3D bioprinting) employed and the physiological relevance of the obtained models in mimicking the features of native intestinal tissue. A major thrust of the manuscript is also on highlighting the dynamic interplay between intestinal cells (both the stem cells and differentiated ones) and different biophysical, biochemical, and mechanobiological cues along with interaction with other cell types and intestinal microbiome, providing goals for the future developments in this sphere. The article also manifests an outlook toward the application of induced pluripotent stem cells in the context of intestinal tissue models. On a concluding note, challenges and prospects for clinical translation of 3D patterned intestinal tissue models have been discussed.

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