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On-line Access: 2021-02-03
Received: 2020-10-17
Revision Accepted: 2020-12-15
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Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects
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Tarun Agarwal, Valentina Onesto, Lallepak Lamboni, Aafreen Ansari, Tapas K. Maiti, Pooyan Makvandi, Massoud Vosough & Guang Yang . Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects[J]. Journal of Zhejiang University Science D, 2021, 4(3): 568-595.
@article{title="Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects",
author="Tarun Agarwal, Valentina Onesto, Lallepak Lamboni, Aafreen Ansari, Tapas K. Maiti, Pooyan Makvandi, Massoud Vosough & Guang Yang ",
journal="Journal of Zhejiang University Science D",
volume="4",
number="3",
pages="568-595",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00120-5"
}
%0 Journal Article
%T Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects
%A Tarun Agarwal
%A Valentina Onesto
%A Lallepak Lamboni
%A Aafreen Ansari
%A Tapas K. Maiti
%A Pooyan Makvandi
%A Massoud Vosough & Guang Yang
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 3
%P 568-595
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-020-00120-5
TY - JOUR
T1 - Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects
A1 - Tarun Agarwal
A1 - Valentina Onesto
A1 - Lallepak Lamboni
A1 - Aafreen Ansari
A1 - Tapas K. Maiti
A1 - Pooyan Makvandi
A1 - Massoud Vosough & Guang Yang
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 3
SP - 568
EP - 595
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-020-00120-5
Abstract: Conventional 2D intestinal models cannot precisely recapitulate biomimetic features in vitro and thus are unsuitable for various pharmacokinetic applications, development of disease models, and understanding the host-microbiome interactions. Thus, recently, efforts have been directed toward recreating in vitro models with intestine-associated unique 3D crypt-villus (for small intestine) or crypt-lumen (for large intestine) architectures. This review comprehensively delineates the current advancements in this research area in terms of the different microfabrication technologies (photolithography, laser ablation, and 3D bioprinting) employed and the physiological relevance of the obtained models in mimicking the features of native intestinal tissue. A major thrust of the manuscript is also on highlighting the dynamic interplay between intestinal cells (both the stem cells and differentiated ones) and different biophysical, biochemical, and mechanobiological cues along with interaction with other cell types and intestinal microbiome, providing goals for the future developments in this sphere. The article also manifests an outlook toward the application of induced pluripotent stem cells in the context of intestinal tissue models. On a concluding note, challenges and prospects for clinical translation of 3D patterned intestinal tissue models have been discussed.
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