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On-line Access: 2021-08-09
Received: 2020-11-12
Revision Accepted: 2021-06-12
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Organoids: anovel modality indisease modeling
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ZahraHeydari, FaridehMoeinvaziri, TarunAgarwal, PariaPooyan, AnastasiaShpichka, TapasK.Maiti, PeterTimashev, HosseinBaharvand, MassoudVosough. Organoids: anovel modality indisease modeling[J]. Journal of Zhejiang University Science D, 2021, 4(4): 689-716.
@article{title="Organoids: anovel modality indisease modeling",
author="ZahraHeydari, FaridehMoeinvaziri, TarunAgarwal, PariaPooyan, AnastasiaShpichka, TapasK.Maiti, PeterTimashev, HosseinBaharvand, MassoudVosough",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="689-716",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00150-7"
}
%0 Journal Article
%T Organoids: anovel modality indisease modeling
%A ZahraHeydari
%A FaridehMoeinvaziri
%A TarunAgarwal
%A PariaPooyan
%A AnastasiaShpichka
%A TapasK.Maiti
%A PeterTimashev
%A HosseinBaharvand
%A MassoudVosough
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 689-716
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00150-7
TY - JOUR
T1 - Organoids: anovel modality indisease modeling
A1 - ZahraHeydari
A1 - FaridehMoeinvaziri
A1 - TarunAgarwal
A1 - PariaPooyan
A1 - AnastasiaShpichka
A1 - TapasK.Maiti
A1 - PeterTimashev
A1 - HosseinBaharvand
A1 - MassoudVosough
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 689
EP - 716
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00150-7
Abstract: Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more accurately. Recent advances in the improvement of protocols have resulted in
establishing three-dimensional (3D) organ-like architectures called organoids that can display the characteristics of their
corresponding real organs, including morphological features, functional activities, and personalized responses to specifc
pathogens. We discuss diferent organoid-based 3D models herein, which are classifed based on their original germinal layer.
Studies of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating
practical knowledge along with preclinical studies, including drug screening, toxicology, and molecular pathophysiology of
diseases. This paper also outlines the key challenges, advantages, and prospects of current organoid systems.
Open peer comments: Debate/Discuss/Question/Opinion
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