Full Text:   <1506>

CLC number: 

On-line Access: 2021-08-09

Received: 2020-11-12

Revision Accepted: 2021-06-12

Crosschecked: 0000-00-00

Cited: 0

Clicked: 1795

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2021 Vol.4 No.4 P.689-716

http://doi.org/10.1007/s42242-021-00150-7


Organoids: a novel modality in disease modeling


Author(s):  Zahra Heydari, Farideh Moeinvaziri, Tarun Agarwal, Paria Pooyan, Anastasia Shpichka, Tapas K. Maiti, Peter Timashev, Hossein Baharvand, Massoud Vosough

Affiliation(s):  Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 14155-4364, Iran; more

Corresponding email(s):   timashev_p_s@staf.sechenov.ru, baharvand@Royaninstitute.org, masvos@Royaninstitute.org

Key Words:  Organoid, Germ layer, Disease modeling, Drug screening


Share this article to: More

Zahra Heydari, Farideh Moeinvaziri, Tarun Agarwal, Paria Pooyan, Anastasia Shpichka, Tapas K. Maiti, Peter Timashev, Hossein Baharvand, Massoud Vosough. Organoids: a novel modality in disease modeling[J]. Journal of Zhejiang University Science D, 2021, 4(4): 689-716.

@article{title="Organoids: a novel modality in disease modeling",
author="Zahra Heydari, Farideh Moeinvaziri, Tarun Agarwal, Paria Pooyan, Anastasia Shpichka, Tapas K. Maiti, Peter Timashev, Hossein Baharvand, Massoud Vosough",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="689-716",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00150-7"
}

%0 Journal Article
%T Organoids: a novel modality in disease modeling
%A Zahra Heydari
%A Farideh Moeinvaziri
%A Tarun Agarwal
%A Paria Pooyan
%A Anastasia Shpichka
%A Tapas K. Maiti
%A Peter Timashev
%A Hossein Baharvand
%A Massoud Vosough
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 689-716
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00150-7

TY - JOUR
T1 - Organoids: a novel modality in disease modeling
A1 - Zahra Heydari
A1 - Farideh Moeinvaziri
A1 - Tarun Agarwal
A1 - Paria Pooyan
A1 - Anastasia Shpichka
A1 - Tapas K. Maiti
A1 - Peter Timashev
A1 - Hossein Baharvand
A1 - Massoud Vosough
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 689
EP - 716
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00150-7


Abstract: 
Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more accurately. Recent advances in the improvement of protocols have resulted in establishing three-dimensional (3D) organ-like architectures called ‘organoids’ that can display the characteristics of their corresponding real organs, including morphological features, functional activities, and personalized responses to specifc pathogens. We discuss diferent organoid-based 3D models herein, which are classifed based on their original germinal layer. Studies of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating practical knowledge along with preclinical studies, including drug screening, toxicology, and molecular pathophysiology of diseases. This paper also outlines the key challenges, advantages, and prospects of current organoid systems.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2023 Journal of Zhejiang University-SCIENCE