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Bio-Design and Manufacturing  2023 Vol.6 No.5 P.563–585

http://doi.org/10.1007/s42242-023-00241-7


Recent advances in lung-on-a-chip technology for modeling respiratory disease


Author(s):  Jorge A. Tavares-Negrete, Prativa Das, Sahar Najafikhoshnoo, Steven Zanganeh & Rahim Esfandyarpour

Affiliation(s):  Department of Electrical Engineering, University of California, Irvine, CA 92697, USA; more

Corresponding email(s):   rahimes@uci.edu

Key Words:  Lung-on-a-chip, In vitro modeling, Lung pathophysiology, Respiratory diseases, 3D culture model


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Jorge A. Tavares-Negrete, Prativa Das, Sahar Najafikhoshnoo, Steven Zanganeh & Rahim Esfandyarpour. Recent advances in lung-on-a-chip technology for modeling respiratory disease[J]. Journal of Zhejiang University Science D, 2023, 6(5): 563–585.

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Abstract: 
Tissue engineering approaches, including those to functional lung tissues, are finely honed by the inclusion of upgraded devices that mimic biophysical and biochemical features in vivo. Perfusion culture is one of these essential biophysical characteristics enabled by the introduction of microfluidic devices in recent years. This review links the importance of dynamic culture for in vitro maintenance of functional lung cells to the modeling of respiratory disease. We identify and discuss different parameters for fabricating the requisite microfluidic models for lung cells, as well as their application in modeling lung diseases caused by external factors such as smoking and pollution. The possibility of creating a multi-organ-on-a-chip to establish a more physiologically relevant model is highlighted. Overall, the focus is on different prospects for the in vitro modeling approach and for lungs-on-a-chip for developing advanced, reliable technology to analyze the pathophysiology of respiratory diseases and screen potential treatments.

加州大学尔湾分校Rahim Esfandyarpour等 | 综述:用于模拟呼吸系统疾病的肺芯片技术最新进展

本综述论文聚焦用于模拟呼吸系统疾病的肺芯片技术的最新进展。随着模拟体内生物物理和生化特征的设备升级,组织工程方法(包括功能性肺组织方法)得到了完善。灌注培养是近年来随着微流控设备的引入而实现的基本生物物理特性之一。本综述将动态培养对体外维持肺细胞功能的重要性与呼吸系统疾病建模联系起来。探讨了构建肺细胞微流控模型所需的不同参数,以及它们在模拟吸烟、污染等外部因素引起的肺部疾病中的应用。强调了创建多器官芯片以建立更符合生理学的模型的可能性。综上,本文分别针对体外肺模型的构建方法和以肺器官芯片开发先进可靠的技术,从而分析呼吸系统疾病的病理生理学和筛选潜在的治疗方法,提出了其研究前景。

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