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Bio-Design and Manufacturing  2022 Vol.5 No.1 P.14-42

http://doi.org/10.1007/s42242-021-00165-0


3D bioprinting: current status and trends—a guide to the literature and industrial practice


Author(s):  Silvia Santoni, Simone G. Gugliandolo, Mattia Sponchioni, Davide Moscatelli & Bianca M. Colosimo

Affiliation(s):  Department of Mechanical Engineering, Politecnico di Milano, Via La Masa, 1, 20156, Milan, Italy; more

Corresponding email(s):   mattia.sponchioni@polimi.it

Key Words:  Additive manufacturing, 3D bioprinting, Biofabrication, Organ-on-a-chip, Tissue engineering


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Silvia Santoni, Simone G. Gugliandolo, Mattia Sponchioni, Davide Moscatelli & Bianca M. Colosimo. 3D bioprinting: current status and trends—a guide to the literature and industrial practice[J]. Journal of Zhejiang University Science D, 2022, 5(1): 14-42.

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Abstract: 
The multidisciplinary research field of bioprinting combines additive manufacturing, biology and material sciences to create bioconstructs with three-dimensional architectures mimicking natural living tissues. The high interest in the possibility of reproducing biological tissues and organs is further boosted by the ever-increasing need for personalized medicine, thus allowing bioprinting to establish itself in the field of biomedical research, and attracting extensive research efforts from companies, universities, and research institutes alike. In this context, this paper proposes a scientometric analysis and critical review of the current literature and the industrial landscape of bioprinting to provide a clear overview of its fast-changing and complex position. The scientific literature and patenting results for 2000–2020 are reviewed and critically analyzed by retrieving 9314 scientific papers and 309 international patents in order to draw a picture of the scientific and industrial landscape in terms of top research countries, institutions, journals, authors and topics, and identifying the technology hubs worldwide. This review paper thus offers a guide to researchers interested in this field or to those who simply want to understand the emerging trends in additive manufacturing and 3D bioprinting.

米兰理工大学Mattia Sponchioni等 | 生物3D打印的现状与趋势——科学文献与产业实践指南

本综述聚焦生物3D打印的学科发展与产业现状。生物3D打印是一个多学科交叉的研究领域,将增材制造、生物学和材料科学结合起来,制造出具有模仿自然活体组织的三维结构的生物结构。对个性化医学日益增长的需求进一步激发了人们对制造出功能化组织器官的高度兴趣,从而使生物3D打印在生物医学研究领域成为研究热门,并吸引了公司、大学和研究机构的广泛研究努力。在这种背景下,本文提出了一项科学计量分析方法来批判性综述当前有关生物3D打印的文献以及产业发展情况,以提供一个清晰的概述来说明其快速变化的发展趋势。本文通过检索9314篇科学论文和309项国际专利,对2000-2020年的科学文献和专利申请结果进行了总结和批判性分析,来描绘这一新兴技术的顶级研究国家、机构、期刊、作者和热门主题的科研和产业全景,以此来确定全球的生物3D打印技术中心。因此,这篇综述文章为对该领域感兴趣的研究人员或那些只是想简单了解下增材制造和生物3D打印新趋势的人们提供了研究指南。

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