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Bio-Design and Manufacturing  2022 Vol.5 No.2 P.233-248

http://doi.org/10.1007/s42242-022-00184-5


Adhesion-enhancing coating embedded with osteogenesis-promoting PDA/HA nanoparticles for peri-implant soft tissue sealing and osseointegration


Author(s):  Tingshu Su, Ao Zheng, Lingyan Cao, Lingjie Peng, Xiao Wang, Jie Wang, Xianzhen Xin & Xinquan Jiang

Affiliation(s):  Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; more

Corresponding email(s):   kristyxxz@126.com, xinquanjiang@aliyun.com

Key Words:  Dental implantation, Multifunctional coating, Titanium, Osseointegration, Soft tissue sealing


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Tingshu Su, Ao Zheng, Lingyan Cao, Lingjie Peng, Xiao Wang, Jie Wang, Xianzhen Xin & Xinquan Jiang. Adhesion-enhancing coating embedded with osteogenesis-promoting PDA/HA nanoparticles for peri-implant soft tissue sealing and osseointegration[J]. Journal of Zhejiang University Science D, 2022, 5(2): 233-248.

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Abstract: 
Following dental implantation, the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation, which can negatively impact osseointegration and cause implant failure. To improve soft tissue sealing around the implant, enhance osseointegration, and improve implant success rates, this paper proposes a composite multifunctional coating (PHG) prepared using gelatin and polydopamine/hydroxyapatite nanoparticles, investigates the effects of this novel coating on cell adhesion, proliferation, antibacterial activity, osteogenic differentiation, and evaluates its immune-related properties. The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment. Furthermore, it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts, indicating its adhesion-promoting effect. Additionally, bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces. Notably, the PHG coating exhibited antibacterial activity against Streptococcus mutans, as well as anti-inflammatory effects, potentially via the regulation of macrophages. Therefore, the proposed PHG coating may promote soft tissue sealing and bone bonding, providing a potential strategy for the surface modification of dental implants.

【封面文章】上海交大口腔医学院/第九人民医院 | PDA/HA明胶改性多功能涂层促进种植体周围软组织封闭及骨结合

本研究论文来自蒋欣泉教授团队,文章聚焦牙列缺损/缺失的种植修复治疗,开发了一种新型多功能种植体表面涂层。钛作为牙科种植体的主要材料被广泛应用,但仍然存在种植体表面生物活性较低等不足。本研究利用聚多巴胺(PDA)的高黏附性和机械性能以及明胶优良的亲水性、生物相容性和促细胞黏附性能,设计制备了一种聚多巴胺-羟基磷灰石-明胶(PHG)复合多功能涂层来改善钛种植体的表面性能。研究表明该表面PHG复合多功能涂层具有良好的亲水性、光热效应和稳定性。进一步通过探究该涂层对细胞黏附、增殖和成骨分化等的影响,以及其对口腔常见致病细菌变形链球菌(S.mutans)的抗菌性能,发现PHG涂层具有良好的生物相容性,能够促人牙龈成纤维细胞黏附生长、促骨髓间充质干细胞成骨分化,并显著抑制S.mutans活性。本研究证实新型PHG有可能作为一种钛种植体的表面改性方法,提高种植体表面的生物活性,使其具有良好的生物相容性、抗菌能力,同时促进种植体骨结合和软组织封闭,可为设计新型钛种植体表面改性方法和材料提供新的策略。


(苏庭舒医生和郑奥博士为共同第一作者,忻贤贞医生为共同通讯作者)

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