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On-line Access: 2022-02-19

Received: 2021-07-23

Revision Accepted: 2022-01-11

Crosschecked: 2022-02-19

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Bio-Design and Manufacturing  2022 Vol.5 No.2 P.233-248

http://doi.org/10.1007/s42242-022-00184-5


Adhesion-enhancing coating embedded with osteogenesis-promoting PDA/HA nanoparticles for peri-implant soft tissue sealing and osseointegration


Author(s):  Tingshu Su, Ao Zheng, Lingyan Cao, Lingjie Peng, Xiao Wang, Jie Wang, Xianzhen Xin & Xinquan Jiang

Affiliation(s):  Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; more

Corresponding email(s):   kristyxxz@126.com, xinquanjiang@aliyun.com

Key Words:  Dental implantation, Multifunctional coating, Titanium, Osseointegration, Soft tissue sealing


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Tingshu Su, Ao Zheng, Lingyan Cao, Lingjie Peng, Xiao Wang, Jie Wang, Xianzhen Xin & Xinquan Jiang. Adhesion-enhancing coating embedded with osteogenesis-promoting PDA/HA nanoparticles for peri-implant soft tissue sealing and osseointegration[J]. Journal of Zhejiang University Science D, 2022, 5(2): 233-248.

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Abstract: 
Following dental implantation, the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation, which can negatively impact osseointegration and cause implant failure. To improve soft tissue sealing around the implant, enhance osseointegration, and improve implant success rates, this paper proposes a composite multifunctional coating (PHG) prepared using gelatin and polydopamine/hydroxyapatite nanoparticles, investigates the effects of this novel coating on cell adhesion, proliferation, antibacterial activity, osteogenic differentiation, and evaluates its immune-related properties. The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment. Furthermore, it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts, indicating its adhesion-promoting effect. Additionally, bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces. Notably, the PHG coating exhibited antibacterial activity against Streptococcus mutans, as well as anti-inflammatory effects, potentially via the regulation of macrophages. Therefore, the proposed PHG coating may promote soft tissue sealing and bone bonding, providing a potential strategy for the surface modification of dental implants.

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