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The feasible application of microfluidic tissue/organ-on-a-chip as an impersonator of oral tissues and organs: a direction for future research
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Nima Farshidfar, Sahar Assar, Mohammad Amin Amiri, Sarina Sahmeddini, Shahram Hamedani, Moein Zarei & Lobat Tayebi. The feasible application of microfluidic tissue/organ-on-a-chip as an impersonator of oral tissues and organs: a direction for future research[J]. Journal of Zhejiang University Science D, 2023, 6(4): 478-506.
@article{title="The feasible application of microfluidic tissue/organ-on-a-chip
as an impersonator of oral tissues and organs: a direction for future
research",
author="Nima Farshidfar, Sahar Assar, Mohammad Amin Amiri, Sarina Sahmeddini, Shahram Hamedani, Moein Zarei & Lobat Tayebi",
journal="Journal of Zhejiang University Science D",
volume="6",
number="4",
pages="478-506",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00235-5"
}
%0 Journal Article
%T The feasible application of microfluidic tissue/organ-on-a-chip
as an impersonator of oral tissues and organs: a direction for future
research
%A Nima Farshidfar
%A Sahar Assar
%A Mohammad Amin Amiri
%A Sarina Sahmeddini
%A Shahram Hamedani
%A Moein Zarei & Lobat Tayebi
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 4
%P 478-506
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00235-5
TY - JOUR
T1 - The feasible application of microfluidic tissue/organ-on-a-chip
as an impersonator of oral tissues and organs: a direction for future
research
A1 - Nima Farshidfar
A1 - Sahar Assar
A1 - Mohammad Amin Amiri
A1 - Sarina Sahmeddini
A1 - Shahram Hamedani
A1 - Moein Zarei & Lobat Tayebi
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 4
SP - 478
EP - 506
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00235-5
Abstract: Currently, cell culture models play a key role in determining cell behavior under various conditions. However, the accurate
simulation of cellular behavior that imitates the body’s conditions remains a challenge. Therefore, to overcome this obstacle,
three-dimensional cell culture models have been developed. Microfluidic tissues/organs-on-chips (TOOCs) are new devices
that have provided the opportunity to culture cells in a medium that is almost similar to the physiological conditions of the
body. TOOCs can be designed in simple or complex models, which are mostly fabricated by soft lithography. These novel
structures have been developed to mimic the conditions of various tissues and organs; however, microfluidic models for oral
and dental tissues have not yet been widely used. The application of TOOCs for oral tissues/organs can provide the opportunity
to study cell interactions with biomaterials used in dentistry. Furthermore, TOOCs can provide the opportunity to study the
cellular interactions and developmental stages of oral tissues/organs more accurately. This review of the current advances in
the field of TOOC development for oral tissues provides a comprehensive understanding of this burgeoning concept, shows
the progress and applications of these novel models in the imitation of oral tissues/organs thus far, and reveals the limitations
that TOOCs confront. Moreover, it suggests further perspectives for future applications.
本综述论文聚焦微流控组织/器官芯片作为口腔组织和器官模仿器的可行应用。目前，细胞培养模型在确定各种条件下的细胞行为方面发挥着关键作用。然而，准确模拟仿生理状况的细胞行为仍然是一个挑战。为了克服这一挑战，研究人员已经尝试开发了三维细胞培养模型。微流体组织/器官芯片（TOOC）是一种新装置，它为研究人员提供了在几乎与身体生理条件相似的培养基中培养细胞的可能性。TOOC可以设计成简单或复杂的模型，这些模型大多通过软光刻制造。这些新颖的结构已被开发用于模拟各种组织和器官的状况；然而，口腔和牙齿组织的微流体模型尚未得到广泛应用。TOOC在口腔组织/器官中的应用可以提供研究细胞与牙科中使用的生物材料的相互作用的机会。此外，TOOC可以提供更准确地研究口腔组织/器官的细胞相互作用和发育阶段的机会。本文综述了口腔组织TOOC开发领域的当前进展，全面了解了这一新兴概念，展示了迄今为止这些新模型在口腔组织/器官模仿方面的进展和应用，并揭示了TOOC面临的局限性。此外，还讨论了未来的应用前景。
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