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CLC number: R318.08

On-line Access: 2019-10-09

Received: 2019-09-04

Revision Accepted: 2019-09-11

Crosschecked: 2019-09-12

Cited: 0

Clicked: 2113

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Hong Zhang

https://orcid.org/0000-0002-4084-5150

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.11 P.865-867

http://doi.org/10.1631/jzus.B1900535


Automated microfluidic chip system for radiosynthesis of PET imaging probes


Author(s):  Ming Lei, Jian-zhang Pan, Guang-ming Xu, Pei-zhen Du, Mei Tian, Hong Zhang

Affiliation(s):  PET Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   meitian@zju.edu.cn, hzhang21@zju.edu.cn

Key Words:  Positron emission tomography (PET), Molecular imaging probe, Modularization, Automated microfluidic chip system


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Ming Lei, Jian-zhang Pan, Guang-ming Xu, Pei-zhen Du, Mei Tian, Hong Zhang. Automated microfluidic chip system for radiosynthesis of PET imaging probes[J]. Journal of Zhejiang University Science B, 2019, 20(11): 865-867.

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Abstract: 
positron emission tomography (PET) is a powerful non-invasive molecular imaging technique for the early detection, characterization, and “real-time” monitoring of disease, and for investigating the efficacy of drugs (Phelps, 2000; Ametamey et al., 2008). The development of molecular probes bearing short-lived positron-emitting radionuclides, such as 18F (half-life 110 min) or 11C (half-life 20 min), is crucial for PET imaging to collect in vivo metabolic information in a time-efficient manner (Deng et al., 2019). In this regard, one of the main challenges is rapid synthesis of radiolabeled probes by introducing the radionuclides into pharmaceuticals as soon as possible before injection for a PET scan. Although many potential PET probes have been discovered, only a handful can satisfy the demand for a highly efficient synthesis procedure that achieves radiolabeling and delivery for imaging within 1–2 radioisotope half-lives. Only a few probes, such as 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) and [18F]fluorodopa, are routinely produced on a commercial scale for daily clinical diagnosis (Grayson et al., 2018; Carollo et al., 2019).

PET分子影像探针微流控芯片自动合成系统

概要:放射性核素标记的分子影像探针是支撑正电子发射断层成像(PET)分子影像和核医学诊断应用的关键.微流控芯片自动合成系统可以根据各种不同PET分子影像探针的合成工艺,灵活组合微流控芯片模块,微量且高效地合成不同类型的PET分子影像探针.这种自动合成系统的成功研制对发展现代PET分子影像技术具有重要意义.
关键词:PET分子影像探针;微流控芯片;模块化;自动合成仪

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Reference

[1]Ametamey SM, Honer M, Schubiger PA, 2008. Molecular imaging with PET. Chem Rev, 108(5):1501-1516.

[2]Arima V, Pascali G, Lade O, et al., 2013. Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab Chip, 13(12):2328-2336.

[3]Carollo A, Papi S, Grana CM, et al., 2019. State of the art and recent developments of radiopharmaceuticals for pancreatic neuroendocrine tumors imaging. Curr Radiopharm, 12(2):107-125.

[4]Deng XY, Rong J, Wang L, et al., 2019. Chemistry for positron emission tomography: recent advances in 11C-, 18F-, 13N-, and 15O-labeling reactions. Angew Chem Int Ed, 58(9): 2580-2605.

[5]Grayson PC, Alehashemi S, Bagheri AA, et al., 2018. 18F-fluorodeoxyglucose–positron emission tomography as an imaging biomarker in a prospective, longitudinal cohort of patients with large vessel vasculitis. Arthritis Rheumatol, 70(3):439-449.

[6]Lee CC, Sui GD, Elizarov A, et al., 2005. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science, 310(5755):1793-1796.

[7]Pascali G, Watts P, Salvadori PA, 2013. Microfluidics in radiopharmaceutical chemistry. Nucl Med Biol, 40(6): 776-787.

[8]Phelps ME, 2000. Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci USA, 97(16):9226-9233.

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