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CLC number: R318.08

On-line Access: 2019-10-09

Received: 2019-09-04

Revision Accepted: 2019-09-11

Crosschecked: 2019-09-12

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Hong Zhang


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.11 P.865-867


Automated microfluidic chip system for radiosynthesis of PET imaging probes

Author(s):  Ming Lei, Jian-zhang Pan, Guang-ming Xu, Pei-zhen Du, Mei Tian, Hong Zhang

Affiliation(s):  PET Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   meitian@zju.edu.cn, hzhang21@zju.edu.cn

Key Words:  Positron emission tomography (PET), Molecular imaging probe, Modularization, Automated microfluidic chip system

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Ming Lei, Jian-zhang Pan, Guang-ming Xu, Pei-zhen Du, Mei Tian, Hong Zhang. Automated microfluidic chip system for radiosynthesis of PET imaging probes[J]. Journal of Zhejiang University Science B, 2019, 20(11): 865-867.

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positron emission tomography (PET) is a powerful non-invasive molecular imaging technique for the early detection, characterization, and “real-time” monitoring of disease, and for investigating the efficacy of drugs (Phelps, 2000; Ametamey et al., 2008). The development of molecular probes bearing short-lived positron-emitting radionuclides, such as 18F (half-life 110 min) or 11C (half-life 20 min), is crucial for PET imaging to collect in vivo metabolic information in a time-efficient manner (Deng et al., 2019). In this regard, one of the main challenges is rapid synthesis of radiolabeled probes by introducing the radionuclides into pharmaceuticals as soon as possible before injection for a PET scan. Although many potential PET probes have been discovered, only a handful can satisfy the demand for a highly efficient synthesis procedure that achieves radiolabeling and delivery for imaging within 1–2 radioisotope half-lives. Only a few probes, such as 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) and [18F]fluorodopa, are routinely produced on a commercial scale for daily clinical diagnosis (Grayson et al., 2018; Carollo et al., 2019).



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[2]Arima V, Pascali G, Lade O, et al., 2013. Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab Chip, 13(12):2328-2336.

[3]Carollo A, Papi S, Grana CM, et al., 2019. State of the art and recent developments of radiopharmaceuticals for pancreatic neuroendocrine tumors imaging. Curr Radiopharm, 12(2):107-125.

[4]Deng XY, Rong J, Wang L, et al., 2019. Chemistry for positron emission tomography: recent advances in 11C-, 18F-, 13N-, and 15O-labeling reactions. Angew Chem Int Ed, 58(9): 2580-2605.

[5]Grayson PC, Alehashemi S, Bagheri AA, et al., 2018. 18F-fluorodeoxyglucose–positron emission tomography as an imaging biomarker in a prospective, longitudinal cohort of patients with large vessel vasculitis. Arthritis Rheumatol, 70(3):439-449.

[6]Lee CC, Sui GD, Elizarov A, et al., 2005. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science, 310(5755):1793-1796.

[7]Pascali G, Watts P, Salvadori PA, 2013. Microfluidics in radiopharmaceutical chemistry. Nucl Med Biol, 40(6): 776-787.

[8]Phelps ME, 2000. Positron emission tomography provides molecular imaging of biological processes. Proc Natl Acad Sci USA, 97(16):9226-9233.

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