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Ang LI


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.6 P.437-450


Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis

Author(s):  Jiaqi LU, Jingyuan LIU, Ang LI

Affiliation(s):  Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Corresponding email(s):   liang@ccmu.edu.cn

Key Words:  Sepsis, Neutrophils, Oxidative stress, Reactive oxygen species (ROS), Organ dysfunction

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Jiaqi LU, Jingyuan LIU, Ang LI. Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis[J]. Journal of Zhejiang University Science B, 2022, 23(6): 437-450.

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author="Jiaqi LU, Jingyuan LIU, Ang LI",
journal="Journal of Zhejiang University Science B",
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%0 Journal Article
%T Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis
%A Jiaqi LU
%A Jingyuan LIU
%A Ang LI
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 6
%P 437-450
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2101075

T1 - Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis
A1 - Jiaqi LU
A1 - Jingyuan LIU
A1 - Ang LI
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 6
SP - 437
EP - 450
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2101075

sepsis is a condition of severe organ failure caused by the maladaptive response of the host to an infection. It is a severe complication affecting critically ill patients, which can progress to severe sepsis, septic shock, and ultimately death. As a vital part of the human innate immune system, neutrophils are essential in resisting pathogen invasion, infection, and immune surveillance. Neutrophil-produced reactive oxygen species (ROS) play a pivotal role in organ dysfunction related to sepsis. In recent years, ROS have received a lot of attention as a major cause of sepsis, which can progress to severe sepsis and septic shock. This paper reviews the existing knowledge on the production mechanism of neutrophil ROS in human organ function impairment because of sepsis.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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