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 ORCID:

Ang LI

https://orcid.org/0000-0002-1478-3072

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.6 P.437-450

http://doi.org/10.1631/jzus.B2101075


Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis


Author(s):  Jiaqi LU, Jingyuan LIU, Ang LI

Affiliation(s):  Intensive Care Unit, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Corresponding email(s):   liang@ccmu.edu.cn

Key Words:  Sepsis, Neutrophils, Oxidative stress, Reactive oxygen species (ROS), Organ dysfunction


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Jiaqi LU, Jingyuan LIU, Ang LI. Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis[J]. Journal of Zhejiang University Science B, 2022, 23(6): 437-450.

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%T Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis
%A Jiaqi LU
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T1 - Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis
A1 - Jiaqi LU
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A1 - Ang LI
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2101075


Abstract: 
sepsis is a condition of severe organ failure caused by the maladaptive response of the host to an infection. It is a severe complication affecting critically ill patients, which can progress to severe sepsis, septic shock, and ultimately death. As a vital part of the human innate immune system, neutrophils are essential in resisting pathogen invasion, infection, and immune surveillance. Neutrophil-produced reactive oxygen species (ROS) play a pivotal role in organ dysfunction related to sepsis. In recent years, ROS have received a lot of attention as a major cause of sepsis, which can progress to severe sepsis and septic shock. This paper reviews the existing knowledge on the production mechanism of neutrophil ROS in human organ function impairment because of sepsis.

中性粒细胞活性氧生成在脓毒症器官功能损害中的作用

卢嘉琪,刘景院,李昂
首都医科大学附属北京地坛医院重症医学科,中国北京市,100015
概要:脓毒症是由宿主对感染的不良反应引起的严重器官衰竭的综合征。中性粒细胞作为人类固有免疫系统的重要组成部分,对抵抗病原体入侵、感染和免疫监视至关重要。中性粒细胞产生的活性氧(ROS)在与脓毒症相关的器官功能障碍中起关键作用。脓毒症可发展为严重脓毒症和感染性休克,因此近年来ROS作为脓毒症的一个因素受到了很多关注。本综述旨在总结中性粒细胞ROS在脓毒症器官功能损害中的适当机制,并有望为脓毒症期间破坏性器官功能障碍的发生和发展提供新的线索。

关键词:脓毒症;中性粒细胞;氧化应激;活性氧;器官功能障碍

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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