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Bio-Design and Manufacturing  2023 Vol.6 No.6 P.691-703


Rapid printing of 3D porous scaffolds for breast reconstruction

Author(s):  Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang & Yong He

Affiliation(s):  School of Mechatronics and Vehicle Engineering, East China Jiaotong University, Nanchang 330013, China; more

Corresponding email(s):   jxliuyd@163.com, jiwang1004@zju.edu.cn, yongqin@zju.edu.cn

Key Words:  Projection-based 3D bioprinting (PBP), F127DA, Breast reconstruction, Fat transplantation

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Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang & Yong He. Rapid printing of 3D porous scaffolds for breast reconstruction[J]. Journal of Zhejiang University Science D, 2023, 6(6): 691-703.

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author="Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang & Yong He",
journal="Journal of Zhejiang University Science D",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Rapid printing of 3D porous scaffolds for breast reconstruction
%A Pengcheng Zhao
%A Biling Wang
%A Lu Wang
%A Zexin Fu
%A Jun Hu
%A Yande Liu
%A Ji Wang & Yong He
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 6
%P 691-703
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00253-3

T1 - Rapid printing of 3D porous scaffolds for breast reconstruction
A1 - Pengcheng Zhao
A1 - Biling Wang
A1 - Lu Wang
A1 - Zexin Fu
A1 - Jun Hu
A1 - Yande Liu
A1 - Ji Wang & Yong He
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 6
SP - 691
EP - 703
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00253-3

Prosthesis implantation and fat transplantation are common breast reconstruction methods. In general, prosthesis implantation alone does not achieve a realistic enough appearance, and fat transplantation alone is difficult to achieve in the correct capacity. To date, no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction. Using a newly designed bionic ink (i.e., polyether F127 diacrylate (f127DA) & poly(ethylene glycol) diacrylate (PEGDA)) and projection-based three-dimensional bioprinting (PBP), we report the development of a new method for printing porous prostheses. PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of f127DA and reducing the impact of external temperature. The compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural breasts. Finally, stromal vascular fraction gel (SVF-gel), a human fat extract, was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue. These were implanted subcutaneously in nude mice to observe their biological performance. After 14 and 28 days of observation, the prosthesis showed good biocompatibility, and adipose tissues grew well in and around the prosthesis. This result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.

浙江省人民医院吴溯帆、浙江大学贺永团队 | 生物3D打印在乳房重建中的探索


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