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On-line Access: 2023-11-29

Received: 2023-02-14

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Bio-Design and Manufacturing  2023 Vol.6 No.6 P.691-703

http://doi.org/10.1007/s42242-023-00253-3


Rapid printing of 3D porous scaffolds for breast reconstruction


Author(s):  Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang & Yong He

Affiliation(s):  School of Mechatronics and Vehicle Engineering, East China Jiaotong University, Nanchang 330013, China; more

Corresponding email(s):   jxliuyd@163.com, jiwang1004@zju.edu.cn, yongqin@zju.edu.cn

Key Words:  Projection-based 3D bioprinting (PBP), F127DA, Breast reconstruction, Fat transplantation


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Pengcheng Zhao, Biling Wang, Lu Wang, Zexin Fu, Jun Hu, Yande Liu, Ji Wang & Yong He. Rapid printing of 3D porous scaffolds for breast reconstruction[J]. Journal of Zhejiang University Science D, 2023, 6(6): 691-703.

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Abstract: 
Prosthesis implantation and fat transplantation are common breast reconstruction methods. In general, prosthesis implantation alone does not achieve a realistic enough appearance, and fat transplantation alone is difficult to achieve in the correct capacity. To date, no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction. Using a newly designed bionic ink (i.e., polyether F127 diacrylate (f127DA) & poly(ethylene glycol) diacrylate (PEGDA)) and projection-based three-dimensional bioprinting (PBP), we report the development of a new method for printing porous prostheses. PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of f127DA and reducing the impact of external temperature. The compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural breasts. Finally, stromal vascular fraction gel (SVF-gel), a human fat extract, was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue. These were implanted subcutaneously in nude mice to observe their biological performance. After 14 and 28 days of observation, the prosthesis showed good biocompatibility, and adipose tissues grew well in and around the prosthesis. This result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.

浙江省人民医院吴溯帆、浙江大学贺永团队 | 生物3D打印在乳房重建中的探索

本研究论文聚焦于将3D打印多孔假体与脂肪胶(SVF-gel)结合应用于乳房重建。乳腺癌是全球女性中最常见的癌症,占所有女性癌症的三分之一。大部分女性选择了全乳房切除手术治疗,这种方式可能会让她们产生焦虑和抑郁,而乳房重建则可以改善乳房缺失女性的心理、身体和性健康。目前,乳房切除术后乳房重建的主要方式是自体脂肪填充和假体再造。其中,自体脂肪填充需要大量的脂肪,以及它的流动性较大导致乳房塑形相对困难,这需要外科医生丰富的经验才能做到。而另一种乳房重建的方法就是假体再造,假体较自体脂肪具有更好的塑形能力以及可定制化,但这种方式对生物材料的依赖性较大。本研究提供了一种生物相容性良好的生物墨水组合(PEGDA&F127DA),使用投影式生物3D打印工艺制造出多孔的假体。该假体表现出类似自然乳房的模量以及良好的生物相容性。同时将植入了SVF-gel的假体植入到裸鼠体内的观察结果发现,该方法运用了自体脂肪和假体的优势,达到了乳房重建的效果。相信在不久的将来,这种结合假体再造和自体脂肪填充的方式将在乳房重建中有较好的应用场景。

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