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Bio-Design and Manufacturing  2023 Vol.6 No.6 P.617-645

http://doi.org/10.1007/s42242-023-00261-3


Biomanufacturing in Japan: frontier research from 2018 to 2023


Author(s):  Qing Cao, Yangqianhui Zhang, Runyi Deng, Kai Ren, Huayong Yang & Dong Han

Affiliation(s):  State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   dong_han@zju.edu.cn

Key Words:  Biomanufacturing (BM), Japan, Biomedical materials, Bio-3D printing, Biomedical applications


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Qing Cao, Yangqianhui Zhang, Runyi Deng, Kai Ren, Huayong Yang & Dong Han. Biomanufacturing in Japan: frontier research from 2018 to 2023[J]. Journal of Zhejiang University Science D, 2023, 6(6): 617-645.

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Abstract: 
biomanufacturing (BM) is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors, including medicine, energy, and the environment. BM has undergone a remarkable transformation in the last two decades, entering the era of BM 4.0 and becoming a pivotal driver of the sustainable revolution. Notably, japan has made significant advances in BM, contributing to its development through the creation of innovative materials, advanced processes, and interdisciplinary applications. However, because of certain development policies, this research has not been widely recognized on an international level. This paper provides a comprehensive summary of the research progress made by renowned japanese laboratories and researchers in biomedical materials, bio-three-dimensional (3D) printing, and biomedical applications in the last five years. Their unique contributions are introduced and analyzed, illuminating the distinctive approaches and breakthroughs within each domain. Additionally, this review highlights the current challenges and prospects of BM. The viewpoints presented in this paper are intended to serve as a valuable reference for scholars studying BM in japan.

浙大机院韩冬等|日本生物制造前沿研究-2018-2023

本综述论文聚焦近5年日本在生物制造领域的最新研究进展。生物制造(BM)是一个跨学科领域,它利用生物体的特性和工程学原理,生产可用于医药、能源、环境等领域的高附加值产品。在过去的二十年里,BM经历了一个显著的转变,进入了4.0时代,并成为可持续革命的关键驱动力。值得注意的是,日本在BM上取得了重大进展,包括新型材料、先进工艺和多学科上的应用等。然而,由于某些发展政策的原因,相关研究尚未在国际上得到广泛关注。在本综述中,我们全面概述了日本著名实验室和学者在生物医用材料、生物3D打印和生物医学应用方面的研究进展。同时,也指出了目前日本BM存在的挑战和前景。本文提出的观点旨在为后续研究学者提供有价值的参考。

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