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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B23Z0004


Two-step internal/external polydopamine (Cu2+) modified bioceramic scaffolds enhance antibacterial and alveolar bone regeneration capability


Author(s):  Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN

Affiliation(s):  Department of Oral Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.; more

Corresponding email(s):   chenlili_1030@zju.edu.cn, zhrgou@zju.edu.cn

Key Words:  Polydopamine (Cu2+) modification, Antibacterial properties, Bone regeneration, Angiogenesis, Bioceramic scaffolds.


Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN. Two-step internal/external polydopamine (Cu2+) modified bioceramic scaffolds enhance antibacterial and alveolar bone regeneration capability[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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%T Two-step internal/external polydopamine (Cu2+) modified bioceramic scaffolds enhance antibacterial and alveolar bone regeneration capability
%A Xiaojian JIANG
%A Lihong LEI
%A Weilian SUN
%A Yingming WEI
%A Jiayin HAN
%A Shuaiqi ZHONG
%A Xianyan YANG
%A Zhongru GOU
%A Lili CHEN
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%I Zhejiang University Press & Springer
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T1 - Two-step internal/external polydopamine (Cu2+) modified bioceramic scaffolds enhance antibacterial and alveolar bone regeneration capability
A1 - Xiaojian JIANG
A1 - Lihong LEI
A1 - Weilian SUN
A1 - Yingming WEI
A1 - Jiayin HAN
A1 - Shuaiqi ZHONG
A1 - Xianyan YANG
A1 - Zhongru GOU
A1 - Lili CHEN
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
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%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B23Z0004


Abstract: 
Magnesium-doped calcium silicate (CS) bioceramic scaffolds have unique advantages in mandibular defect repair; however, they lack antibacterial properties to cope with the complex oral microbiome. Herein, for the first time, the CS scaffold was functionally modified with a novel polydopamine (PDA) copper (PDA(Cu2+)) rapid deposition method, to construct internal modified (*P), external modified (@PDA) and dual modified (*P@PDA) scaffolds. The morphology, degradation behavior and mechanical properties of the obtained scaffolds were evaluated in vitro. The results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical resistance. During the prolonged immersion stage, the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained release. The in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA, while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis effects. Finally, the PDA(Cu2+) modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect model. Overall, it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu2+) modification, and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.

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