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Review Microneedles for Non-Transdermal Drug Delivery: Design Strategies and Current Applications
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Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu. Review Microneedles for Non-Transdermal Drug Delivery: Design Strategies and Current Applications[J]. Journal of Zhejiang University Science D, 2025, 8(1): 1-19.
@article{title="Review Microneedles for Non-Transdermal Drug Delivery: Design Strategies
and Current Applications",
author="Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu",
journal="Journal of Zhejiang University Science D",
volume="8",
number="1",
pages="1-19",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2300352"
}
%0 Journal Article
%T Review Microneedles for Non-Transdermal Drug Delivery: Design Strategies
and Current Applications
%A Jinhong Xu
%A Xiangyi Liao
%A Danli Chen
%A Xiuzhuo Jia
%A Xufeng Niu
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 1
%P 1-19
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2300352
TY - JOUR
T1 - Review Microneedles for Non-Transdermal Drug Delivery: Design Strategies
and Current Applications
A1 - Jinhong Xu
A1 - Xiangyi Liao
A1 - Danli Chen
A1 - Xiuzhuo Jia
A1 - Xufeng Niu
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 1
SP - 1
EP - 19
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2300352
Abstract: Microneedles (MNs) are an innovative and viable option for drug delivery that offer the distinct advantages of minimal inva‐
siveness, painlessness, stable drug loading, efficient drug permeation, and biocompatibility. MNs were first used to penetrate
the skin surface and facilitate transcutaneous drug delivery with great success. Recent applications of MNs have extended to
non-transdermal drug delivery, specifically, to various tissues and organs. This review captures the fabrication methods for
MNs, discusses advanced design strategies for achieving controlled drug release, and summarizes current MN applications in
delivering multiple therapeutic agents to the cardiovascular, digestive (e.g., oral cavity), reproductive, and central nervous
systems. The findings in this review would contribute toward the improved designs of MN systems that can be modified ac‐
cording to purpose, including material selection, structural design, choice of fabrication methods, and tissue considerations,
to determine the optimal therapeutic regimen for the target treatment area
Open peer comments: Debate/Discuss/Question/Opinion
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