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On-line Access: 2024-12-17
Received: 2023-09-20
Revision Accepted: 2024-09-15
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Magnesium and gallium coloaded microspheres accelerate bone repair via osteogenesis and antibiosis
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Jin Bai, Si Shen, Yan Liu, Shendan Xu, Tianqi Li, Zirou Wang, Weili Liu, Lingling Pu, Gang Chen, Xinxing Wang. Magnesium and gallium coloaded microspheres accelerate bone repair via osteogenesis and antibiosis[J]. Journal of Zhejiang University Science D, 2025, 8(1): 150-165.
@article{title="Magnesium and gallium coloaded microspheres accelerate bone repair via
osteogenesis and antibiosis",
author="Jin Bai, Si Shen, Yan Liu, Shendan Xu, Tianqi Li, Zirou Wang, Weili Liu, Lingling Pu, Gang Chen, Xinxing Wang",
journal="Journal of Zhejiang University Science D",
volume="8",
number="1",
pages="150-165",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2300253"
}
%0 Journal Article
%T Magnesium and gallium coloaded microspheres accelerate bone repair via
osteogenesis and antibiosis
%A Jin Bai
%A Si Shen
%A Yan Liu
%A Shendan Xu
%A Tianqi Li
%A Zirou Wang
%A Weili Liu
%A Lingling Pu
%A Gang Chen
%A Xinxing Wang
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 1
%P 150-165
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2300253
TY - JOUR
T1 - Magnesium and gallium coloaded microspheres accelerate bone repair via
osteogenesis and antibiosis
A1 - Jin Bai
A1 - Si Shen
A1 - Yan Liu
A1 - Shendan Xu
A1 - Tianqi Li
A1 - Zirou Wang
A1 - Weili Liu
A1 - Lingling Pu
A1 - Gang Chen
A1 - Xinxing Wang
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 1
SP - 150
EP - 165
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2300253
Abstract: Bone defects have serious economic and clinical impacts; however, despite improvements in bone defect management, the
range of clinical outcomes remains limited. A variety of biomaterials have been used to treat complex bone defects. How?
ever, final bone repair outcomes may be adversely affected by poor osteogenic capacity and risk of infection. Consequently,
therapeutic methods are required that reduce bacterial contamination and increase the use of osteogenic biomaterials. Herein,
we report the preparation of poly (lactic acid-coglycolic acid) (PLGA) microspheres coloaded with magnesium (Mg2+) and
gallium (Ga3+) ions (Mg-Ga@PLGA), which can fill irregular bone defects and show good biosafety. During in vitro testing,
Mg-Ga@PLGA not only showed a synergistic effect on promoting osteogenic differentiation but also inhibited osteoclastic
differentiation. Moreover, we also found that Mg-Ga@PLGA demonstrated a strong antibacterial effect. In vivo, MgGa@PLGA exhibited strong in situ osteogenic ability. In conclusion, Mg-Ga@PLGA has good potential for treating bone
defects at risk of infection.
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