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On-line Access: 2021-06-18
Received: 2021-01-07
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Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats
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Zhiyong Zeng,Guohua Jiang,Tianqi Liu, Gao Song,Yanfang Sun, Xueya Zhang, Yanting Jing,Mingjia Feng,Yufei Shi. Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats[J]. Journal of Zhejiang University Science D, 2021, 4(4): 902-911.
@article{title="Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats",
author="Zhiyong Zeng,Guohua Jiang,Tianqi Liu, Gao Song,Yanfang Sun, Xueya Zhang, Yanting Jing,Mingjia Feng,Yufei Shi",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="902-911",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00140-9"
}
%0 Journal Article
%T Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats
%A Zhiyong Zeng
%A Guohua Jiang
%A Tianqi Liu
%A Gao Song
%A Yanfang Sun
%A Xueya Zhang
%A Yanting Jing
%A Mingjia Feng
%A Yufei Shi
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 902-911
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00140-9
TY - JOUR
T1 - Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats
A1 - Zhiyong Zeng
A1 - Guohua Jiang
A1 - Tianqi Liu
A1 - Gao Song
A1 - Yanfang Sun
A1 - Xueya Zhang
A1 - Yanting Jing
A1 - Mingjia Feng
A1 - Yufei Shi
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 902
EP - 911
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00140-9
Abstract: Injection therapy for diabetes has poor patient compliance, and the pain occurring at the site of subcutaneous injections
causes signifcant inconvenience to diabetic patients. In this work, to demonstrate the benefts of an alternative drug delivery
technique that overcomes these issues, methacrylated gelatin hydrogel-forming microneedles integrated with metformin
were developed to adjust blood glucose levels in diabetic rats. Gelatin methacryloyl microneedles (GelMA-MNs) with dif-ferent degrees of substitution were successfully prepared by a micro-molding method. The resultant GelMA-MNs exhibited
excellent mechanical properties and moisture resistance. Metformin, an anti-diabetic drug, was further encapsulated into
the GelMA-MNs, and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,
thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic efect compared with that of
subcutaneous injection in diabetic rats. The drug release period could be signifcantly prolonged by improving the cross-link density of GelMA-MNs. The results of hypoglycemic efect evaluation show that the application of GelMA-MNs for
transdermal delivery in diabetic rats has promising benefts for diabetes treatment.
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