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On-line Access: 2025-01-07
Received: 2023-12-23
Revision Accepted: 2024-09-13
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Reduced graphene oxide-mediated electronhole separation using titanium dioxide increases the photocatalytic antibacterial activity of bone scaffolds
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Pei Feng, Haifeng Tian, Feng Yang, Shuping Peng, Hao Pan, Cijun Shuai. Reduced graphene oxide-mediated electronhole separation using titanium dioxide increases the photocatalytic antibacterial activity of bone scaffolds[J]. Journal of Zhejiang University Science D, 2025, 8(1): 100-115.
@article{title="Reduced graphene oxide-mediated electronhole separation using titanium dioxide
increases the photocatalytic antibacterial activity of bone scaffolds",
author="Pei Feng, Haifeng Tian, Feng Yang, Shuping Peng, Hao Pan, Cijun Shuai",
journal="Journal of Zhejiang University Science D",
volume="8",
number="1",
pages="100-115",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2300372"
}
%0 Journal Article
%T Reduced graphene oxide-mediated electronhole separation using titanium dioxide
increases the photocatalytic antibacterial activity of bone scaffolds
%A Pei Feng
%A Haifeng Tian
%A Feng Yang
%A Shuping Peng
%A Hao Pan
%A Cijun Shuai
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 1
%P 100-115
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2300372
TY - JOUR
T1 - Reduced graphene oxide-mediated electronhole separation using titanium dioxide
increases the photocatalytic antibacterial activity of bone scaffolds
A1 - Pei Feng
A1 - Haifeng Tian
A1 - Feng Yang
A1 - Shuping Peng
A1 - Hao Pan
A1 - Cijun Shuai
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 1
SP - 100
EP - 115
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2300372
Abstract: Fast electronhole recombination issues during titanium dioxide (TiO2) photocatalysis limit
its application in preventing bacterial infection during bone defect repair. In this study,
TiO2@reduced graphene oxide (rGO) composites were synthesized using a hydrothermal
method in which rGO, which possesses very high electrical conductivity, promotes the
separation of photoelectronhole pairs of TiO2, thus improving the efficiency of
photocatalytic production of reactive oxygen species (ROS). Subsequently, TiO2@rGO
composites were introduced into poly-L-lactic acid (PLLA) to prepare bone scaffolds with
photocatalytic antibacterial function via selective laser sintering. The results showed that TiO2
grew on the surface of rGO and formed a covalent bond connection (TiOC) with rGO. A
decreased electrochemical impedance of TiO2@rGO composites was observed, and the
transient photocurrent intensity increased from 0.05 to 0.5 ?A/cm2
. Analysis of electron spin
resonance found that the photocatalytic products of TiO2 were OH and O2
?
, two kinds of
ROS capable of killing bacteria via disrupting the structure of the bacterial membrane in vitro.
Antibacterial experiments showed that the antibacterial rates of PLLA/TiO2@rGO scaffolds
against E. coli and S. aureus were 60% and 71%, respectively. Finally, we report that these
scaffolds exhibited both enhanced mechanical properties due to the addition of TiO2@rGO as
a reinforcement material and good biocompatibility during cell proliferation.
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