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On-line Access: 2025-09-06
Received: 2024-09-14
Revision Accepted: 2025-04-01
Crosschecked: 0000-00-00
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Reactive oxygen species scavenging hydrogel for wound healing in diabetic mice
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Kaiyue Liu (刘恺悦), Ruimei Jin (金瑞美), Mengyu Yang (杨孟宇), Yachao Yu (于亚超), Jingmei Liu (刘静美), Chenghao Li (李程皓), Chen Zhang (张晨), Hua Zhao (赵化), Donghui Zhao (赵冬辉), Fangxia Guan (关方霞) & Minghao Yao (姚明浩). Reactive oxygen species scavenging hydrogel for wound healing in diabetic mice[J]. Journal of Zhejiang University Science D, 2025, 8(5): 742-758.
@article{title="Reactive oxygen species scavenging hydrogel for wound healing in
diabetic mice",
author="Kaiyue Liu (刘恺悦), Ruimei Jin (金瑞美), Mengyu Yang (杨孟宇), Yachao Yu (于亚超), Jingmei Liu (刘静美), Chenghao Li (李程皓), Chen Zhang (张晨), Hua Zhao (赵化), Donghui Zhao (赵冬辉), Fangxia Guan (关方霞) & Minghao Yao (姚明浩)",
journal="Journal of Zhejiang University Science D",
volume="8",
number="5",
pages="742-758",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400375"
}
%0 Journal Article
%T Reactive oxygen species scavenging hydrogel for wound healing in
diabetic mice
%A Kaiyue Liu (刘恺悦)
%A Ruimei Jin (金瑞美)
%A Mengyu Yang (杨孟宇)
%A Yachao Yu (于亚超)
%A Jingmei Liu (刘静美)
%A Chenghao Li (李程皓)
%A Chen Zhang (张晨)
%A Hua Zhao (赵化)
%A Donghui Zhao (赵冬辉)
%A Fangxia Guan (关方霞) & Minghao Yao (姚明浩)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 5
%P 742-758
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400375
TY - JOUR
T1 - Reactive oxygen species scavenging hydrogel for wound healing in
diabetic mice
A1 - Kaiyue Liu (刘恺悦)
A1 - Ruimei Jin (金瑞美)
A1 - Mengyu Yang (杨孟宇)
A1 - Yachao Yu (于亚超)
A1 - Jingmei Liu (刘静美)
A1 - Chenghao Li (李程皓)
A1 - Chen Zhang (张晨)
A1 - Hua Zhao (赵化)
A1 - Donghui Zhao (赵冬辉)
A1 - Fangxia Guan (关方霞) & Minghao Yao (姚明浩)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 5
SP - 742
EP - 758
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400375
Abstract: Excessive production of reactive oxygen species (ROS) and bacterial infection are intractable obstacles for wound healing in
diabetic foot ulcers. Here, we devised a novel approach using a multifunctional hydrogel to achieve self-cascade glucose
depletion and ROS scavenging, thereby modifying the diabetic wound microenvironment. In this study, using polyvinyl alcohol
(PVA), borax, oligomeric proanthocyanidins (OPC), and nanozymes (AuPt@PDA), a PVA/Borax/OPC/AuPt@PDA (PBON)
hydrogel was prepared by a one-step process. The PBON hydrogel combined with near-infrared (NIR) treatment can match
the complicated and changeable microenvironment in the diabetic high-mobility region through glucose depletion, ROS scav
enging, photothermal therapy (photothermal conversion 81.9%), and deformation adaptation, thus promoting wound healing
close to the hip in diabetic mice through angiogenesis and epidermal regeneration by collagen deposition. This approach pro
vides a simple, safe, and efficient treatment for diabetic wounds in mobile regions.
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