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On-line Access: 2025-09-19
Received: 2024-12-09
Revision Accepted: 2025-03-23
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Silk fibroin bandage for preventing tendon adhesions
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Pengcheng Xia (???), Guofeng Liu (???), Tianhong Qiao (???), Ke Yao (??), Chaofan He (???), Yong He (??), Jianchao Gui (???) & Yuan Sun (??) . Silk fibroin bandage for preventing tendon adhesions[J]. Journal of Zhejiang University Science D, 2025, 8(5): 800-818.
@article{title="Silk fibroin bandage for preventing tendon adhesions",
author="Pengcheng Xia (???), Guofeng Liu (???), Tianhong Qiao (???), Ke Yao (??), Chaofan He (???), Yong He (??), Jianchao Gui (???) & Yuan Sun (??) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="5",
pages="800-818",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400495"
}
%0 Journal Article
%T Silk fibroin bandage for preventing tendon adhesions
%A Pengcheng Xia (???)
%A Guofeng Liu (???)
%A Tianhong Qiao (???)
%A Ke Yao (??)
%A Chaofan He (???)
%A Yong He (??)
%A Jianchao Gui (???) & Yuan Sun (??)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 5
%P 800-818
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400495
TY - JOUR
T1 - Silk fibroin bandage for preventing tendon adhesions
A1 - Pengcheng Xia (???)
A1 - Guofeng Liu (???)
A1 - Tianhong Qiao (???)
A1 - Ke Yao (??)
A1 - Chaofan He (???)
A1 - Yong He (??)
A1 - Jianchao Gui (???) & Yuan Sun (??)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 5
SP - 800
EP - 818
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400495
Abstract: Tendon adhesion, a prevalent complication affecting over 30% of patients after a tendon injury or surgery, results in joint
stiffness and impaired mobility. Although current treatments facilitate tendon repair, they are often insufficient in preventing
adhesions and promoting optimal healing outcomes. To address these challenges, we developed an oriented cryostructured
silk fibroin bandage (OCSFB) using the directional freeze-casting methodology. In vitro studies demonstrated that OCSFB
provided a favorable microenvironment for cell viability, proliferation, and alignment, concurrently upregulating the expres?
sion of tendon-specific genes. In a rat Achilles tendon model, OCSFB significantly reduced adhesion formation and improved
tendon healing. RNA-seq analysis further revealed modulation of cell adhesion molecules, substantiating its role in tissue
regeneration. The integration of silk fibroin biocompatibility with a unique microstructure that facilitates cellular adhesion
and proliferation renders OCSFB a promising approach for mitigating tendon adhesions and improving repair outcomes,
establishing it as a robust candidate for clinical application.
Open peer comments: Debate/Discuss/Question/Opinion
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