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On-line Access: 2025-07-30
Received: 2024-12-13
Revision Accepted: 2025-02-10
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Bioinspired magnetic microspike robot for long-term drug delivery anchoring on gliomas
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Xingyue Hu, Wen Cheng, Tianyang Ma, Yuting Zhou, Junjian Zhou, Xuechun Wang, Lianqing Liu, Anhua Wu, Guannan He, Niandong Jiao . Bioinspired magnetic microspike robot for long-term drug delivery anchoring on gliomas[J]. Journal of Zhejiang University Science D, 2025, 8(4): 558569.
@article{title="Bioinspired magnetic microspike robot for long-term drug delivery
anchoring on gliomas",
author="Xingyue Hu, Wen Cheng, Tianyang Ma, Yuting Zhou, Junjian Zhou, Xuechun Wang, Lianqing Liu, Anhua Wu, Guannan He, Niandong Jiao ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="4",
pages="558569",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400508"
}
%0 Journal Article
%T Bioinspired magnetic microspike robot for long-term drug delivery
anchoring on gliomas
%A Xingyue Hu
%A Wen Cheng
%A Tianyang Ma
%A Yuting Zhou
%A Junjian Zhou
%A Xuechun Wang
%A Lianqing Liu
%A Anhua Wu
%A Guannan He
%A Niandong Jiao
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 4
%P 558569
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400508
TY - JOUR
T1 - Bioinspired magnetic microspike robot for long-term drug delivery
anchoring on gliomas
A1 - Xingyue Hu
A1 - Wen Cheng
A1 - Tianyang Ma
A1 - Yuting Zhou
A1 - Junjian Zhou
A1 - Xuechun Wang
A1 - Lianqing Liu
A1 - Anhua Wu
A1 - Guannan He
A1 - Niandong Jiao
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 4
SP - 558569
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400508
Abstract: Treatment of intracranial gliomas has increasingly favored minimally invasive surgery, with a growing focus on leveraging
microrobots for efficient drug delivery while overcoming the impact of body fluids. Inspired by honeybee stingers, this study
proposed a novel microspike robot. This robot firmly adhered to the tissue surface, enabling direct drug delivery from a hy?
drogel on its back into the targeted tissue via microspikes. The drug delivery rate was influenced by temperature and could
be controlled by an alternating magnetic field. Microrobots could be delivered rapidly through a clinical Ommaya reservoir
into the postoperative cavity or ventricle of the skull. The microrobot could be actuated for adhesion and retrieval, with its
motion posture and trajectory highly precisely controlled by external magnetic fields. Biological experiments confirmed the
excellent biocompatibility and biosafety of the microspike robot and demonstrated its effectiveness in treating gliomas by
loading unconventional therapeutic drugs. The proposed microspike robot has significant potential for long-term drug deliv?
ery to target gliomas and other future clinical applications.
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