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On-line Access: 2025-11-14
Received: 2025-01-21
Revision Accepted: 2025-06-03
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Bone marrow mesenchymal stem cell-loaded HAMA hydrogel within highly bionic nerve guidance conduits for peripheral nerve regeneration
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Chao Li (??), Li-Fang Zhu (???), Ming-Wei Chang (???), Hao Li (??), Shiheng Liu (???) & Baolin Wang (???). Bone marrow mesenchymal stem cell-loaded HAMA hydrogel within highly bionic nerve guidance conduits for peripheral nerve regeneration[J]. Journal of Zhejiang University Science D, 2025, 8(6): 976-993.
@article{title=" Bone marrow mesenchymal stem cell-loaded HAMA hydrogel within highly
bionic nerve guidance conduits for peripheral nerve regeneration",
author="Chao Li (??), Li-Fang Zhu (???), Ming-Wei Chang (???), Hao Li (??), Shiheng Liu (???) & Baolin Wang (???)",
journal="Journal of Zhejiang University Science D",
volume="8",
number="6",
pages="976-993",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500026"
}
%0 Journal Article
%T Bone marrow mesenchymal stem cell-loaded HAMA hydrogel within highly
bionic nerve guidance conduits for peripheral nerve regeneration
%A Chao Li (??)
%A Li-Fang Zhu (???)
%A Ming-Wei Chang (???)
%A Hao Li (??)
%A Shiheng Liu (???) & Baolin Wang (???)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 6
%P 976-993
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500026
TY - JOUR
T1 - Bone marrow mesenchymal stem cell-loaded HAMA hydrogel within highly
bionic nerve guidance conduits for peripheral nerve regeneration
A1 - Chao Li (??)
A1 - Li-Fang Zhu (???)
A1 - Ming-Wei Chang (???)
A1 - Hao Li (??)
A1 - Shiheng Liu (???) & Baolin Wang (???)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 6
SP - 976
EP - 993
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500026
Abstract: Nerve guidance conduits (NGCs) effectively support and guide the regeneration of injured nerves. However, traditional
NGCs often lack essential growth factors and fail to create a biomimetic microenvironment conducive to nerve regrowth.
This study develops a highly bionic nerve guidance conduit (HB-NGC) using hybrid high-voltage electrotechnologies that in
tegrate electrospinning with electrohydrodynamic (EHD) printing. The outer layer consists of electrospun polycaprolactone
fibers loaded with carboxyl-multi-walled carbon nanotubes, while the inner layer is composed of highly aligned polycapro
lactone fibers created by EHD printing. The tubular core of the HB-NGC is filled with hyaluronic acid methacryloyl
(HAMA) hydrogel encapsulating bone marrow mesenchymal stem cells (BMSCs). This highly biomimetic NGC is conduc
tive, capable of guiding axon growth, and sustainably releases growth factors, effectively mimicking the structure, function,
and characteristics of natural peripheral nerves. Its distinctive architectural layers provide an exceptional bionic microenvi
ronment by restoring physical pathways, facilitating electrical signal conduction, and supplying an extracellular matrix
(ECM) environment enriched with essential growth factors. Additionally, the HB-NGCs morphology, along with its physi
cochemical and mechanical properties, effectively bridges the gap between severed nerve ends. In vivo animal studies vali
date the HB-NGCs effectiveness, highlighting its significant potential to enhance peripheral nerve regeneration.
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