Full Text:
<3>
CLC number:
On-line Access: 2025-07-30
Received: 2025-02-10
Revision Accepted: 2025-02-13
Crosschecked: 0000-00-00
Cited: 0
Clicked: 3
|
Microneedle-loaded hybrid extracellular vesicles promote diabetic wound healing
| |||||||||||||
Yue Sun,Qirong Zhou,Shihao Sheng,Huijian Yang,Long Bai,Zhen Geng,Jian Wang,Ke Xu,Xiao Chen,Yingying Jing,Guangchao Wang,Jiacan Su. Microneedle-loaded hybrid extracellular vesicles promote diabetic wound healing[J]. Journal of Zhejiang University Science D, 2025, 8(4): 656–671.
@article{title="Microneedle-loaded hybrid extracellular vesicles promote diabetic wound
healing",
author="Yue Sun,Qirong Zhou,Shihao Sheng,Huijian Yang,Long Bai,Zhen Geng,Jian Wang,Ke Xu,Xiao Chen,Yingying Jing,Guangchao Wang,Jiacan Su",
journal="Journal of Zhejiang University Science D",
volume="8",
number="4",
pages="656–671",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500061"
}
%0 Journal Article
%T Microneedle-loaded hybrid extracellular vesicles promote diabetic wound
healing
%A Yue Sun
%A Qirong Zhou
%A Shihao Sheng
%A Huijian Yang
%A Long Bai
%A Zhen Geng
%A Jian Wang
%A Ke Xu
%A Xiao Chen
%A Yingying Jing
%A Guangchao Wang
%A Jiacan Su
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 4
%P 656–671
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500061
TY - JOUR
T1 - Microneedle-loaded hybrid extracellular vesicles promote diabetic wound
healing
A1 - Yue Sun
A1 - Qirong Zhou
A1 - Shihao Sheng
A1 - Huijian Yang
A1 - Long Bai
A1 - Zhen Geng
A1 - Jian Wang
A1 - Ke Xu
A1 - Xiao Chen
A1 - Yingying Jing
A1 - Guangchao Wang
A1 - Jiacan Su
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 4
SP - 656–671
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500061
Abstract: Chronic diabetic wounds result from a disrupted microenvironment where oxidative stress, impaired angiogenesis, and per‐
sistent infection create a vicious cycle that delays healing. Unfortunately, existing treatments often fail to address these inter‐
related issues, resulting in suboptimal healing. Here, we propose a base-tip dual-component hydrogel microneedle (MN) system
(GBEVs-pVEGF/AgNPs@MNs), consisting of a tip loaded with plant-bacterial hybrid extracellular vesicles (GBEVs-pVEGF)
and a base containing silver nanoparticles (AgNPs). Upon penetrating the necrotic tissue of diabetic wounds, our multifunc‐
tional MNs could effectively deliver GBEVs-pVEGF, thereby alleviating oxidative stress, promoting cell migration, and facili‐
tating angiogenesis. Additionally, the physical barrier formed by the basal layer synergistically mitigates persistent bacterial
infections during wound healing in conjunction with the antimicrobial agent AgNPs. This multifunctional MN system, inte‐
grating antioxidant, angiogenic, and antimicrobial properties, effectively restores the disrupted wound microenvironment, offer‐
ing significant potential for accelerating diabetic wound healing.
Open peer comments: Debate/Discuss/Question/Opinion
<1>