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On-line Access: 2025-03-15
Received: 2023-12-07
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Microneedles for non-transdermal drug delivery: design strategies and current applications
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Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu. Microneedles for non-transdermal drug delivery: design strategies and current applications[J]. Journal of Zhejiang University Science D, 2025, 8(2): 243274.
@article{title="Microneedles for non-transdermal drug delivery: design strategies and current applications",
author="Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu",
journal="Journal of Zhejiang University Science D",
volume="8",
number="2",
pages="243274",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm2300352"
}
%0 Journal Article
%T Microneedles for non-transdermal drug delivery: design strategies and current applications
%A Jinhong Xu
%A Xiangyi Liao
%A Danli Chen
%A Xiuzhuo Jia
%A Xufeng Niu
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 2
%P 243274
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm2300352
TY - JOUR
T1 - Microneedles for non-transdermal drug delivery: design strategies and current applications
A1 - Jinhong Xu
A1 - Xiangyi Liao
A1 - Danli Chen
A1 - Xiuzhuo Jia
A1 - Xufeng Niu
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 2
SP - 243274
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm2300352
Abstract: Microneedles (MNs) are an innovative and viable option for drug delivery that offer the distinct advantages of minimal inva? siveness, painlessness, stable drug loading, efficient drug permeation, and biocompatibility. MNs were first used to penetrate the skin surface and facilitate transcutaneous drug delivery with great success. Recent applications of MNs have extended to non-transdermal drug delivery, specifically, to various tissues and organs. This review captures the fabrication methods for MNs, discusses advanced design strategies for achieving controlled drug release, and summarizes current MN applications in delivering multiple therapeutic agents to the cardiovascular, digestive (e.g., oral cavity), reproductive, and central nervous systems. The findings in this review would contribute toward the improved designs of MN systems that can be modified ac? cording to purpose, including material selection, structural design, choice of fabrication methods, and tissue considerations, to determine the optimal therapeutic regimen for the target treatment area.
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