Full Text:
<2845>
CLC number: TP391.72
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 5
Clicked: 5543
Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
| |||||||||||||
SHEN Qian-yun, ZHENG Shu-sen. Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays[J]. Journal of Zhejiang University Science A, 2004, 5(2): 222-225.
@article{title="Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays",
author="SHEN Qian-yun, ZHENG Shu-sen",
journal="Journal of Zhejiang University Science A",
volume="5",
number="2",
pages="222-225",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.0222"
}
%0 Journal Article
%T Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
%A SHEN Qian-yun
%A ZHENG Shu-sen
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 2
%P 222-225
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.0222
TY - JOUR
T1 - Identification of genes differentially expressed in monocyte-derived dendritic cells with 1α,25-dihydroxyvitamin D3 using cDNA arrays
A1 - SHEN Qian-yun
A1 - ZHENG Shu-sen
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 2
SP - 222
EP - 225
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.0222
Abstract: In order to study the molecular mechanism of the inhibitory effect of 1,25-dihydroxyvitamin D3 on dendritic cells, experiments were performed using Atlas cDNA expression arrays from Clonetech to identify the differentially expressed genes of dendritic cells by 1,25-dihydroxyvitamin D3. Analysis of cDNA arrays revealed changes in the expression of 9 genes, including those involved in DNA binding and transcription, extracellular cell signaling and communication, intracellular transducers, as well as cell adhesions. The results indicated that a multiple molecular network is involved in the inhibitory role of 1,25-dihydroxyvitamin D3 on dendritic cells. The Atlas Array technology may facilitate the elucidation of complex pharmacological process of 1,25-dihydroxyvitamin D3 on dendritic cells.
[1] Banchereau, J., Steinman, R.M., 1998. Dendritic cells and the control of immunity.Nature,392(6673):245-252.
[2] Berer, A., Stockl, J., Majdic, O., Wagner, T., Kollars, M., Lechner, K., Geissler, K., Oehler, L., 2000. 1,25-dihydroxy vitamin D3inhibits dendritic cell differentiation and maturation in vitro.Exp Hematol,28(5):575-583.
[3] Johansen, C., Iversen, L., Ryborg, A., Kragballe, K., 2000. 1alpha, 25-dihydroxyvitamin D3induced differentiation of cultured human keratinocytes is accompanied by a PKC-independent regulation of AP-1 DNA binding activity.J Invest Dermatol,114(6):1174-1179.
[4] Kreft, B., Brzoska, S., Doehn, C., Daha, M.R., Van der Woude, F.J., Sack, K., 1996. 1,25-dihydroxycholecalciferol enhances the expression of MHC class II antigens and intercellular adhesion molecule-1 by human renal tubular epithelial cells.J Urol,155(4):1448-1453.
[5] Kreutz, M., Andreesen, R., Krause, S.W., Szabo, A., Ritz, E., Reichel, H., 1993. 1,25-dihydroxyvitamin D3production and vitamin D3receptor expression are developmentally regulated during differentiation of human monocytes into macrophages.Blood,82(4):1300-1307.
[6] Lotze, M.T., Jaffe, R., 1999. Cancer.In: Lotze, M.T. and Thomson, A.W., ed., Dendritic Cells. Academic Press, California, USA, p.325.
[7] Muller, K., Haahr, P.M., Diamant, M., Rieneck, K., Kharazmi, A., Bendtzen, K., 1992. 1,25-digydroxyvitamin D3inhibits cytokine production by human blood monocytes at the post-transcriptional level.Cytokine,4(6):506-512.
[8] Murray, G.I., Taylor, M.C., McFadyen, M.C., McKay, J.A., Greenlee, W.F., Burke, M.D., 1997. Tumor-specific expression of cytochrome P450 CYP1B1.Cancer Res,57(14):3026-3031.
[9] Palmer, H.G., Gonzalez-Sancho, J.M., Espada, J., Berciano, M.T., Puig, I., Baulida, J., Quintanilla, M., Lano, A., de Herreros, A.G., Lafarga, M., Munoz, A., 2001. Vitamin D3promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.J Cell Biol,154(2):369-387.
[10] Penna, G., Adorini, L., 2000. 1α,25-dihydroxyvitamin D3inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation.J Immunol,164(5):2405-2411.
[11] Piemonti, L., Monti, P., Marina, S., Fraticelli, P., Leone, B.E., Cin, E.D., Allavena, P., Di Carlo, V., 2000. Vitamin D3affects differentiation, maturation, and function of human monocyte-derived dendritic cells.J Immunol,164(9):4443-4451.
[12] Santelli, G., Califano, D., Chiappetta, G., Vento, M.T., Bartoli, P.C., Zullo, F., Trapasso, F., Viglietto, G., Fusco, A., 1999. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis.Am J Pathol,155(3):799-804.
[13] Van Leeuwen, J.P.T.M., Polos, H.A.P., 1999. Vitamin D: Anticancer and Differentiation.In: Feldman, D., ed., Vitamin D. Academic Press, California, USA, p.1089-1099.
[14] Wang, X., Studzinski, G.P., 2001. Inhibition of p38MAP kinase potentiates the JNK/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells.J Cell Biochem,82(1):68-77.
[15] Zerwekh, J.E., Yu, X.P., Breslau, N.A., Manolagas, S., Pak, C.Y., 1993. Vitamin D receptor quantitation in human blood mononuclear cells in health and disease.Mol Cell Endocrinol,96(1-2):1-6.
[16] Zhu, K.J., Shen, Q.Y., Zheng, M., Mrowietz, U., 2001. Effects of calcitriol and its analogues on interaction of MCP-1 and monocyte-derived dendritic cells in vitro.Acta Pharmacol Sin,22(1):62-65.
Open peer comments: Debate/Discuss/Question/Opinion
<1>