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Abstract: Objective: The aim of the current study was to evaluate the effect of ultraviolet (UV) photofunctionalization of dental titanium implants with exposure to the oral cavity on osseointegration in an animal model. Methods: Forty-eight titanium implants (Camlog^® Conelog^® 4.3 mmx9.0 mm) were placed epicrestally into the edentulous jaws of three minipigs and implant stability was assessed by measuring the implant stability quotient (ISQ). Prior to implantation half of the implants were photofunctionalized with intense UV-light. After three months, the implants were exposed and ISQ was measured again. After six months of implant exposure, the minipigs were sacrificed and the harvested specimens were analyzed using histomorphometric, light, and fluorescence microscopy. Main results: Forty-two of 48 implants osseointegrated. The overall mean bone-implant contact area (BIC) was (64±22)%. No significant differences were found in BIC or ISQ value (multivariate analysis of variance (MANOVA), P>0.05) between implants with and without exposure to UV photofunctionalization. Conclusions: No significant effects were observed on osseointegration of dental titanium implants nine months after exposure of UV photofunctionalization.

牙钛种植体的紫外线光化功能对骨整合的影响

[1]Abboud M, Koeck B, Stark H, et al., 2005. Immediate loading of single-tooth implants in the posterior region. Int J Oral Maxillofac Implants, 20(1):61-68.

[2]Adell R, Lekholm U, Rockler B, et al., 1981. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg, 10(6):387-416.

[3]Aita H, Hori N, Takeuchi M, et al., 2009. The effect of ultraviolet functionalization of titanium on integration with bone. Biomaterials, 30(6):1015-1025.

[4]Att W, Ogawa T, 2012. Biological aging of implant surfaces and their restoration with ultraviolet light treatment: a novel understanding of osseointegration. Int J Oral Maxillofac Implants, 27(4):753-761.

[5]Becker ST, Bolte H, Krapf O, et al., 2009. Endocultivation: 3D printed customized porous scaffolds for heterotopic bone induction. Oral Oncol, 45(11):e181-e188.

[6]Bergkvist G, Nilner K, Sahlholm S, et al., 2009. Immediate loading of implants in the edentulous maxilla: use of an interim fixed prosthesis followed by a permanent fixed prosthesis: a 32-month prospective radiological and clinical study. Clin Implant Dent Relat Res, 11(1):1-10.

[7]Berglundh T, Abrahamsson I, Albouy JP, et al., 2007. Bone healing at implants with a fluoride-modified surface: an experimental study in dogs. Clin Oral Implants Res, 18(2):147-152.

[8]Chuang SK, Wei LJ, Douglass CW, et al., 2002. Risk factors for dental implant failure: a strategy for the analysis of clustered failure-time observations. J Dent Res, 81(8):572-577.

[9]Covani U, Ricci M, Bozzolo G, et al., 2011. Analysis of the pattern of the alveolar ridge remodelling following single tooth extraction. Clin Oral Implants Res, 22(8):820-825.

[10]de Maeztu MA, Braceras I, Alava JI, et al., 2008. Improvement of osseointegration of titanium dental implant surfaces modified with CO ions: a comparative histomorphometric study in beagle dogs. Int J Oral Maxillofac Surg, 37(5):441-447.

[11]Donath K, Breuner G, 1982. A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. J Oral Pathol, 11(4):318-326.

[12]Elsubeihi ES, Heersche JN, 2004. Quantitative assessment of post-extraction healing and alveolar ridge remodelling of the mandible in female rats. Arch Oral Biol, 49(5):401-412.

[13]Eriksen EF, Gundersen HJ, Melsen F, et al., 1984. Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing a kinetic model for matrix and mineral apposition. Metab Bone Dis Relat Res, 5(5):243-252.

[14]Funato A, Ogawa T, 2013. Photofunctionalized dental implants: a case series in compromised bone. Int J Oral Maxillofac Implants, 28(6):1589-1601.

[15]https://doi.org/10.11607/jomi.3232

[16]Funato A, Yamada M, Ogawa T, 2013. Success rate, healing time, and implant stability of photofunctionalized dental implants. Int J Oral Maxillofac Implants, 28(5):1261-1271.

[17]https://doi.org/10.11607/jomi.3263

[18]Heydecke G, McFarland DH, Feine JS, et al., 2004. Speech with maxillary implant prostheses: ratings of articulation. J Dent Res, 83(3):236-240.

[19]Ishii K, Matsuo M, Hoshi N, et al., 2016. Effect of ultraviolet irradiation of the implant surface on progression of periimplantitis—a pilot study in dogs. Implant Dent, 25(1):47-53.

[20]Lentrodt J, Bull HG, 1976. Animal experimental studies on bone regeneration following drilling of the bone. Dtsch Zahnarztl Z, 31(2):115-124 (in German).

[21]Maló P, de Araújo Nobre M, Lopes A, et al., 2012. ‘All-on-4’ immediate-function concept for completely edentulous maxillae: a clinical report on the medium (3 years) and long-term (5 years) outcomes. Clin Implant Dent Relat Res, 14(Suppl 1):e139-e150.

[22]Mehl C, Becker ST, Acil Y, et al., 2013. Impact of vertical loading on the implant-bone interface. Clin Oral Implants Res, 24(8):949-956.

[23]Melas F, Marcenes W, Wright PS, 2001. Oral health impact on daily performance in patients with implant-stabilized overdentures and patients with conventional complete dentures. Int J Oral Maxillofac Implants, 16(5):700-712.

[24]Mosekilde L, 1995. Assessing bone quality—animal models in preclinical osteoporosis research. Bone, 17(4 Suppl):S343-S352.

[25]Mosekilde L, Kragstrup J, Richards A, 1987. Compressive strength, ash weight, and volume of vertebral trabecular bone in experimental fluorosis in pigs. Calcif Tissue Int, 40(6):318-322.

[26]Moy PK, Medina D, Shetty V, et al., 2005. Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants, 20(4):569-577.

[27]Nibali L, 2015. Aggressive periodontitis: microbes and host response, who to blame? Virulence, 6(3):223-228.

[28]Nishimura K, Kato T, Ito T, et al., 2014. Influence of titanium ions on cytokine levels of murine splenocytes stimulated with periodontopathic bacterial lipopolysaccharide. Int J Oral Maxillofac Implants, 29(2):472-477.

[29]https://doi.org/10.11607/jomi.3434

[30]Ogawa T, 2014. Ultraviolet photofunctionalization of titanium implants. Int J Oral Maxillofac Implants, 29(1):e95-e102.

[31]https://doi.org/10.11607/jomi.te47

[32]Ogawa T, Nishimura I, 2003. Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes. Int J Oral Maxillofac Implants, 18(2):200-210.

[33]Park DS, Kim IS, Kim H, et al., 2010. Improved biocompatibility of hydroxyapatite thin film prepared by aerosol deposition. J Biomed Mater Res B Appl Biomater, 94(2):353-358.

[34]Park KH, Koak JY, Kim SK, et al., 2013. The effect of ultraviolet-C irradiation via a bactericidal ultraviolet sterilizer on an anodized titanium implant: a study in rabbits. Int J Oral Maxillofac Implants, 28(1):57-66.

[35]https://doi.org/10.11607/jomi.2638

[36]Pyo SW, Park YB, Moon HS, et al., 2013. Photofunctionalization enhances bone-implant contact, dynamics of interfacial osteogenesis, marginal bone seal, and removal torque value of implants: a dog jawbone study. Implant Dent, 22(6):666-675.

[37]Suzuki S, Kobayashi H, Ogawa T, 2013. Implant stability change and osseointegration speed of immediately loaded photofunctionalized implants. Implant Dent, 22(5):481-490.

[38]Tealdo T, Bevilacqua M, Pera F, et al., 2008. Immediate function with fixed implant-supported maxillary dentures: a 12-month pilot study. J Prosthet Dent, 99(5):351-360.

[39]Urban IA, Jovanovic SA, Lozada JL, 2009. Vertical ridge augmentation using guided bone regeneration (GBR) in three clinical scenarios prior to implant placement: a retrospective study of 35 patients 12 to 72 months after loading. Int J Oral Maxillofac Implants, 24(3):502-510.

[40]van Kampen FM, van der Bilt A, Cune MS, et al., 2004. Masticatory function with implant-supported overdentures. J Dent Res, 83(9):708-711.

[41]Wang R, Hashimoto K, Fujishima A, 1997. Light-induced amphiphilic surfaces. Nature, 388:431-432.

[42]Weinlaender M, Kenney EB, Lekovic V, et al., 1992. Histomorphometry of bone apposition around three types of endosseous dental implants. Int J Oral Maxillofac Implants, 7(4):491-496.

[43]Zarb GA, Schmitt A, 1990. Terminal dentition in elderly patients and implant therapy alternatives. Int Dent J, 40(2):67-73.