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Abstract: We examined the effect of a combination of astaxanthin (AX) supplementation, repeated heat stress, and intermittent reloading (IR) on satellite cells in unloaded rat soleus muscles. Forty-nine male Wistar rats (8-week-old) were divided into control, hind-limb unweighting (HU), IR during HU, IR with AX supplementation, IR with repeated heat stress (41.0–41.5 °C for 30 min), and IR with AX supplementation and repeated heat stress groups. After the experimental period, the antigravitational soleus muscle was analyzed using an immunohistochemical technique. Our results revealed that the combination of dietary AX supplementation and heat stress resulted in protection against disuse muscle atrophy in the soleus muscle. This protective effect may be partially due to a higher satellite cell number in the atrophied soleus muscle in the IR/AX/heat stress group compared with the numbers found in the other groups. We concluded that the combination treatment with dietary AX supplementation and repeated heat stress attenuates soleus muscle atrophy, in part by increasing the number of satellite cells.

虾青素摄入、热应激和间歇式再负荷的联合处理对废用性肌萎缩的肌卫星细胞的影响

[1]Arentson-Lantz EJ, English KL, Paddon-Jones D, et al., 2016. Fourteen days of bed rest induces a decline in satellite cell content and robust atrophy of skeletal muscle fibers in middle-aged adults. J Appl Physiol, 120(8):965-975.

[2]Brooks NE, Myburgh KH, 2014. Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways. Front Physiol, 5:99.

[3]Brooks NE, Cadena SM, Vannier E, et al., 2010. Effects of resistance exercise combined with essential amino acid supplementation and energy deficit on markers of skeletal muscle atrophy and regeneration during bed rest and active recovery. Muscle Nerve, 42(6):927-935.

[4]Dose J, Matsugo S, Yokokawa H, et al., 2016. Free radical scavenging and cellular antioxidant properties of astaxanthin. Int J Mol Sci, 17(1):103.

[5]Dumont NA, Bentzinger CF, Sincennes MC, et al., 2015. Satellite cells and skeletal muscle regeneration. Compr Physiol, 5(3):1027-1059.

[6]Egner IM, Bruusgaard JC, Gundersen K, 2016. Satellite cell depletion prevents fiber hypertrophy in skeletal muscle. Development, 143(16):2898-2906.

[7]Fulle S, Di Donna S, Puglielli C, et al., 2005. Age-dependent imbalance of the antioxidative system in human satellite cells. Exp Gerontol, 40(3):189-197.

[8]Gao CQ, Zhao YL, Li HC, et al., 2015. Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured lantang swine skeletal muscle satellite cells. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 16(6):549-559.

[9]Ikeda Y, Tsuji S, Satoh A, et al., 2008. Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J Neurochem, 107(6):1730-1740.

[10]Kojima A, Goto K, Morioka S, et al., 2007. Heat stress facilitates the regeneration of injured skeletal muscle in rats. J Orthop Sci, 12(1):74-82.

[11]le Grand F, Rudnicki MA, 2007. Skeletal muscle satellite cells and adult myogenesis. Curr Opin Cell Biol, 19(6):628-633.

[12]Matsuba Y, Goto K, Morioka S, et al., 2009. Gravitational unloading inhibits the regenerative potential of atrophied soleus muscle in mice. Acta Physiol, 196(3):329-339.

[13]Naito H, Powers SK, Demirel HA, et al., 2000. Heat stress attenuates skeletal muscle atrophy in hindlimb-unweighted rats. J Appl Physiol, 88(1):359-363.

[14]Oishi Y, Hayashida M, Tsukiashi S, et al., 2009. Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers. J Appl Physiol, 107(5):1612-1621.

[15]Powers SK, 2014. Can antioxidants protect against disuse muscle atrophy? Sports Med, 44(S2):155-165.

[16]Powers SK, Kavazis AN, McClung JM, 2007. Oxidative stress and disuse muscle atrophy. J Appl Physiol, 102(6):2389-2397.

[17]Renault V, Thornell LE, Butler-Browne G, et al., 2002. Human skeletal muscle satellite cells: aging, oxidative stress and the mitotic clock. Exp Gerontol, 37(10-11):1229-1236.

[18]Schiaffino S, Dyar KA, Ciciliot S, et al., 2013. Mechanisms regulating skeletal muscle growth and atrophy. FEBS J, 280(17):4294-4314.

[19]Schultz E, Darr KC, Macius A, 1994. Acute effects of hindlimb unweighting on satellite cells of growing skeletal muscle. J Appl Physiol, 76(1):266-270.

[20]Selsby JT, Dodd SL, 2005. Heat treatment reduces oxidative stress and protects muscle mass during immobilization. Am J Physiol, 289(1):R134-R139.

[21]Shefer G, van de Mark DP, Richardson JB, et al., 2006. Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle. Dev Biol, 294(1):50-66.

[22]Snijders T, Wall BT, Dirks ML, et al., 2014. Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content. Clin Sci (Lond), 126(8):557-566.

[23]Sugiura T, Abe N, Nagano M, et al., 2005. Changes in PKB/Akt and calcineurin signaling during recovery in atrophied soleus muscle induced by unloading. Am J Physiol, 288(5):R1273-R1278.

[24]Uehara K, Goto K, Kobayashi T, et al., 2004. Heat-stress enhances proliferative potential in rat soleus muscle. Jpn J Physiol, 54(3):263-271.

[25]Yoshihara T, Sugiura T, Yamamoto Y, et al., 2015. The response of apoptotic and proteolytic systems to repeated heat stress in atrophied rat skeletal muscle. Physiol Rep, 3(10):e12597.

[26]https://doi.org/10.14814/phy2.12597

[27]Yoshihara T, Yamamoto Y, Shibaguchi T, et al., 2017. Dietary astaxanthin supplementation attenuates disuse-induced muscle atrophy and myonuclear apoptosis in the rat soleus muscle. J Physiol Sci, 67(1):181-190.