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Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes
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Qi-Hua HUA, Xuechun ZHANG, Ruifeng TIAN, Zhigang SHE, Zan HUANG. Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes",
author="Qi-Hua HUA, Xuechun ZHANG, Ruifeng TIAN, Zhigang SHE, Zan HUANG",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400127"
}
%0 Journal Article
%T Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes
%A Qi-Hua HUA
%A Xuechun ZHANG
%A Ruifeng TIAN
%A Zhigang SHE
%A Zan HUANG
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400127
TY - JOUR
T1 - Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes
A1 - Qi-Hua HUA
A1 - Xuechun ZHANG
A1 - Ruifeng TIAN
A1 - Zhigang SHE
A1 - Zan HUANG
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400127
Abstract: megakaryocytes and hepatocytes are unique cells in mammals that undergo polyploidization through endomitosis in terminal differentiation. Many polyploidization regulators and underlying mechanisms have been reported, most of which are tightly coupled with development, organogenesis, and cell differentiation. However, the nature of endomitosis, which involves successful entry into and exit from mitosis without complete cytokinesis, has not been fully elucidated yet. We highlight that endomitosis is a new cell fate in the cell Cycle, and tetraploidy is a critical stage at the bifurcation of cell fate decision. This review will summarize the recent research progress in this area and provide novel insights into how cells manipulate mitosis toward endomitosis. Endomitotic cells can evade the tetraploidy restrictions and proceed to multiple rounds of the cell Cycle. This knowledge not only deepens our understanding of endomitosis as a fundamental biological process but also offers new perspectives on the physiological and pathophysiological implications of polyploidization.
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