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Emerging role of the metabolite succinate in bone-related diseases
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Zuping WU, Qiaoli DAI, Ying WANG, Na WU, Chenyu WANG, Jiejun SHI. Emerging role of the metabolite succinate in bone-related diseases[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Emerging role of the metabolite succinate in bone-related diseases",
author="Zuping WU, Qiaoli DAI, Ying WANG, Na WU, Chenyu WANG, Jiejun SHI",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400406"
}
%0 Journal Article
%T Emerging role of the metabolite succinate in bone-related diseases
%A Zuping WU
%A Qiaoli DAI
%A Ying WANG
%A Na WU
%A Chenyu WANG
%A Jiejun SHI
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400406
TY - JOUR
T1 - Emerging role of the metabolite succinate in bone-related diseases
A1 - Zuping WU
A1 - Qiaoli DAI
A1 - Ying WANG
A1 - Na WU
A1 - Chenyu WANG
A1 - Jiejun SHI
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400406
Abstract: Bone-related diseases, including osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), fractures, and periodontitis, significantly impact human health. succinate, primarily known as a metabolic intermediate in the tricarboxylic acid (TCA) cycle, has emerged as a regulator of cellular functions beyond its metabolic role. Under stress, succinate accumulates in mitochondria and acts as a signaling molecule, modulating cellular processes. Notably, succinate activates angiogenesis and inflammation by stabilizing hypoxia-inducible factor 1 alpha (HIF-1α). Moreover, it influences various pathophysiological processes by interacting with the succinate receptor (SUCNR-1), thereby impacting immune response, inflammation, cancer metastasis, and bone homeostasis. The multifaceted roles of succinate as a signaling molecule vary depending on its cellular location and concentration. Recent metabolomic analyses have revealed elevated succinate levels in bone-related diseases, indicating its potential association with these conditions. The objective of this review is to elucidate the impact of succinate on different bone-related diseases and to discuss potential therapeutic targets and drug molecules based on its mechanisms of action.
Open peer comments: Debate/Discuss/Question/Opinion
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