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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200211


Circular RNAs: typical biomarkers for bone-related diseases


Author(s):  Linghui HU, Wei WU, Jun ZOU

Affiliation(s):  School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China

Corresponding email(s):   junzou@sus.edu.cn

Key Words:  Circular RNAs, Bone-related diseases, CeRNA, MicroRNAs


Linghui HU, Wei WU, Jun ZOU. Circular RNAs: typical biomarkers for bone-related diseases[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
Bone is a connective tissue that has important functions in the human body. Cells and the extracellular matrix (ECM) are key components of bone and are closely related to bone-related diseases. However, the outcomes of conventional treatments for bone-related diseases are not promising, hence it is necessary to elucidate the exact regulatory mechanisms of bone-related diseases and identify novel biomarkers for diagnosis and therapy. circular RNAs (circRNAs) are single-stranded RNAs that form closed circular structures without a 5’ cap or 3’ tail and polycyclic adenylate tails. Due to their high stability, circRNAs have the potential to be typical biomarkers. Accumulating evidence suggests that circRNAs are involved in bone-related diseases, including osteoarthritis, osteoporosis, osteosarcoma, multiple myeloma, intervertebral disc degeneration, and rheumatoid arthritis. Herein, we summarize the recent research progress on the characteristics and functions of circRNAs, and highlight the regulatory mechanism of circRNAs in bone-related diseases.

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